An observational study in Covid19, Acute Respiratory Failure and Corona Virus Infection, sponsored by Hospital Universitari Vall d'Hebron Research Institute. Completed at 10 sites in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-04-13.
Sponsored by Hospital Universitari Vall d'Hebron Research Institute · Observational
COVID-19 pneumonia can cause severe acute hypoxemic respiratory failure. The usefulness of noninvasive respiratory support (NIRS), by means of nasal high-flow oxygen (NHFO), continuous positive airway pressure (CPAP), or noninvasive ventilation (NIV), established outside the intensive care unit, is unknown. The aim of this multicenter, retrospective, longitudinal study is to compare the effectiveness of these treatments to prevent death or endotracheal intubation at day 28, and what factors, related to the disease or to the characteristics of the treatment itself, can condition its success or failure.
Multicenter, retrospective, longitudinal study in consecutive adult COVID-19 patients with acute respiratory failure, requiring noninvasive respiratory support (NIRS) outside the intensive care unit (ICU) in 10 hospitals in Catalonia (Spain). Demographic, laboratory, clinical and noninvasive respiratory support data will be collected and analyzed according to the primary outcome (death or endotracheal intubation at day 28) and secondary outcomes (see the dedicated section).
During the hospitalization, patients were treated according to the standard procedures of the participating centers. This study is observational and no randomization have been performed.
Patients were followed up to either 28-days or hospital discharge if still hospitalized at day 28 from NIRS initiation.
7,638 studies on the registry are indexed under COVID-19; 488 are open to participants now.
This study's enrollment of 367 is above the median of 260 across 3,135 observational studies indexed under COVID-19.
Browse COVID-19 studies →Hospital Universitari Vall d'Hebron Research Institute is the lead sponsor of 268 studies on the registry; 61 are open to participants now.
Counted across the registry records on this site, refreshed daily.
COVID19 patients treated by noninvasive respiratory support (nasal high-flow oxygen, CPAP, or noninvasive ventilation), initiated outside the intensive care unit.
Exclusion Criteria:
Device: High-flow nasal cannula treatment
Device: Continuous positive airway pressure (CPAP) treatment
Device: Noninvasive ventilation treatment
Standard operating procedures represented by hihg-flow nasal cannula oxygen therapy
Standard operating procedures represented by continuous positive airway pressure (CPAP) therapy
Standard operating procedures represented by noninvasive ventilation treatment
Treatment failure
Death or endotracheal intubation
Time frame: 28 days within noninvasive respiratory support initiation
28-day mortality
Time frame: 28 days within noninvasive respiratory support initiation
Hospital mortality
Any death during hospital stay
Time frame: Until 28 days from noninvasive respiratory support initiation
Endotracheal intubation
Time frame: 28 days within noninvasive respiratory support initiation
Duration of hospital stay
Time between admission and discharge from hospital or death in hospital
Time frame: Until 28 days from noninvasive respiratory support initiation
This study is completed, as verified in Apr 2021. You cannot join it, but the record below documents what was studied.
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Hospital Universitari Vall d'Hebron Research Institute