An interventional study of Creatine-guanidinoacetic acid and Inulin in Sarcopenia, sponsored by University of Novi Sad, Faculty of Sport and Physical Education. Completed at 1 site in Serbia. Open to participants aged 65 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-01.
Sponsored by University of Novi Sad, Faculty of Sport and Physical Education · Not applicable, Interventional, and Basic science
Sarcopenia-driven brain and muscle creatine deficit could be seen as a distinctive pathological facet of this condition, and this might be approached with targeted therapies in aim to restore creatine homeostasis in target tissues. Among potential therapeutic candidates, guanidinoacetate (GAA) appears recently as a direct precursor of creatine that may favorably upregulate muscle and brain creatine concentration. Interestingly, GAA-creatine mixture was found to be superior than creatine itself to effectively improves bioenergetics in the human brain and muscle in healthy humans, perhaps due to the unique transportability features of this combination. Here, we plan to evaluate does creatine-GAA supplementation affects various biomarkers of sarcopenia in elderly.
1,242 studies on the registry are indexed under Sarcopenia; 405 are open to participants now.
This study's enrollment of 30 is below the median of 60 across 793 interventional studies indexed under Sarcopenia.
Browse Sarcopenia studies →University of Novi Sad, Faculty of Sport and Physical Education is the lead sponsor of 22 studies on the registry; none are open to participants now.
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Exclusion Criteria:
2 grams of creatine and 2 grams of GAA Administered one dose two times per day on an empty stomach in the morning and at the evening
Dietary Supplement: Creatine-guanidinoacetic acid
4 grams of inulin Administered one dose two times per day on an empty stomach in the morning and at the evening
Other: Inulin
A dietary supplement provided as powder dissolved in a glass of water
A dietary supplement provided as powder dissolved in a glass of water
Change in muscular strength
Baseline vs. 6 months
Time frame: Baseline vs. 6 months post-intervention
Change in muscle mass
Baseline vs. 6 months
Time frame: Baseline vs. 6 months post-intervention
Change in muscle metabolites evaluated with MR spectroscopy
Baseline vs. 6 months
Time frame: Baseline vs. 6 months post-intervention
Change in cognitive performance evaluated with Mini-Mental State Exam test
Baseline vs. 6 months
Time frame: Baseline vs. 6 months post-intervention
Change in serum creatine
Baseline vs. 6 months
Time frame: Baseline vs. 6 months post-intervention
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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University of Novi Sad, Faculty of Sport and Physical Education