An interventional study of MUTARS® modular reconstruction prostheses in Knee Disease and Bone Cancer, sponsored by University Hospital, Lille. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-21.
Sponsored by University Hospital, Lille · Not applicable, Interventional, and Other
The placement of mega knee prosthesis is a necessity after a large tumor resection and oncological. These mega knee prostheses implanted in the context of oncological surgery have been very few evaluated in the literature.
Active knee extension is essential in order to walk properly. The study propose the evaluation of this prosthesis by checking the possibility of locking of the prosthetic joint and thus the possibility of active walking.
A more in-depth, isokinetic analysis at 1 year of follow-up will also be done in an exploratory manner, as the literature has no data on this subject.
322 studies on the registry are indexed under Bone Neoplasms; 81 are open to participants now.
This study's enrollment of 9 is below the median of 50 across 218 interventional studies indexed under Bone Neoplasms.
Browse Bone Neoplasms studies →University Hospital, Lille is the lead sponsor of 625 studies on the registry; 141 are open to participants now.
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Exclusion Criteria:
Patients with knee bone malignancy
Procedure: MUTARS® modular reconstruction prostheses
Patients with MUTARS® modular reconstruction prostheses following primary or secondary knee bone malignancy with minimal follow-up of one year
Rate of patients with active locking of the operated knee
rate of patients with successful locking will be estimated by the frequency observed Active locking of the operated knee
Time frame: Baseline
Measurement of joint amplitudes
Functional results of patients with medullary reconstruction prosthesis,joint amplitudes in flexion-extension and in active, passive,
Time frame: Baseline
Presence of frontal and sagittal laxity
Functional results of patients with medullary reconstruction prosthesis
Time frame: Baseline
Musculoskeletal Tumour Society Scoring System (MSTS)
The MSTS Score may be used as a functional measure for patients with sarcoma involving the upper limb. The score includes 6 measures (pain, function, emotional acceptance, hand position, manual dexterity, lifting ability) each measure with a maximum of 5 points. The maximum overall score is 30 points. The score is designed to be used after the procedure and is therefore only collected post-operatively.
Time frame: Baseline
Oxford knee score
The Oxford Knee Score (OKS) is a Patient Reported Outcome questionnaire that was developed to specifically assess the patient's perspective of outcome following Total Knee Arthroplasty. Each of the 12 answers are assigned the previously defined number of points. They range from 1 = least difficult to 5 = most difficult. The 12 ratings are then added together to give a total score used to assess the patient. Functional results of patients with medullary reconstruction prosthesis
Time frame: Baseline
KOOS for the daily impact (subjective score)
The Knee injury and Osteoarthritis Outcome Score (KOOS) is a patient-reported outcome measurement instrument, developed to assess the patient's opinion about their knee and associated problems Functional results of patients with medullary reconstruction prosthesis
Time frame: Baseline
International Knee Society (IKS) score
International Knee Society score : range 0 to 200, a higher score means a better outcome Functional results of patients with medullary reconstruction prosthesis
Time frame: Baseline
Radiological evaluation
Radiological results of patients with medullary reconstruction prosthesis Radiological criterion : Lower limb axis,Blackburn and Peel index for patellar height, Radiological signs of loosening
Time frame: Baseline
Isokinetic strength of the quadriceps and ischio-leg muscles during knee flexion and extension by isokinetic machine type Contrex®.
Muscle recovery of the operated limb compared to the healthy limb
Time frame: Baseline
The test angular velocities are 60°/s and 180°/s in concentric contraction mode by isokinetic machine type Contrex®.
Muscle recovery of the operated limb compared to the healthy limb .
Time frame: Baseline
This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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University Hospital, Lille