An interventional study of Heated Humidified High-Flow Nasal Cannula in Critically Illness, sponsored by Shin Kong Wu Ho-Su Memorial Hospital. Completed. Open to participants aged 20 Years to 100 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-09-25.
Sponsored by Shin Kong Wu Ho-Su Memorial Hospital · Not applicable, Interventional, and Prevention
The purpose of this study is to assess the efficacy of Heated Humidified High-Flow Nasal Cannula compared with noninvasive positive-pressure ventilation in the prevention of extubation failure in patients with prolonged mechanical ventilation.
There have been many clinical trials comparing the role of Heated Humidified High-Flow Nasal Cannula or Noninvasive positive pressure ventilation in the prevention of extubation failure.
These review all have similar results summarized here:
Compared with Noninvasive positive pressure ventilation, Heated Humidified High-Flow Nasal Cannula provides better patient comfort, fewer oxygen desaturation episodes, lower likelihood of interface displacement, and, lower reintubation rate than Noninvasive positive pressure ventilation.
However, most of these clinical trials focused on participants experiencing acute respiratory failure.
Investigators of this study want to find something difference between oh these two groups.
Shin Kong Wu Ho-Su Memorial Hospital is the lead sponsor of 65 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Noninvasive Ventilation group initial setting： Insp. Pressure：12 \~ 16 centimeter of water Exp. Pressure ： 4 \~ 6 centimeter of water FiO2：Keep oxygen saturation measured by pulse oximeter：\> 92% By condition, gradually tap 2\~3 centimeter of water inspiratory positive airway pressure Keep Tidal volume：6\~10 ml/kg
Device: Heated Humidified High-Flow Nasal Cannula
Heated Humidified High-Flow Nasal Cannula group initial setting： Flow setting: 50 L/m FiO2：Keep oxygen saturation measured by pulse oximeter \> 92% temperature:37 ℃ By condition, gradually tap Flow 5 L/m
Device: Heated Humidified High-Flow Nasal Cannula
Participants using of invasive ventilator more than 14 days, maybe considered transferred to the Respiratory Care Center(RCC), participants enrolled to this study and also written informed consent from participants or their family; After extubation, the difficult weaning patients were allocated to two treatment groups, and randomly assigned to Heated Humidified High-Flow Nasal Cannula or Noninvasive Ventilation devices.
Also known as: Noninvasive Ventilation
Re-intubation rate
Any placement of an endotracheal tube for any indication within 72 hours of extubation, censored at the first of hospital discharge or 72 hours after extubation.
Time frame: within 72 hours of extubation
Mortality rate
Mortality rate, or death rate is a measure of the number of deaths
Time frame: up to 3 months
No study locations are listed for this record.
This study is completed, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
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Shin Kong Wu Ho-Su Memorial Hospital