An interventional study of Lactose Free 1% Milk and Lactose Free 1% Milk + 10 g prebiotic in Physiological Stress, Cognitive Change and Gastrointestinal Health, sponsored by University of Illinois at Urbana-Champaign. Completed at 1 site in United States. Open to participants aged 25 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-09-16.
Sponsored by University of Illinois at Urbana-Champaign · Not applicable, Interventional, and Basic science
This research intervention aims to examine the effects of prebiotic consumption on changes in behavioral and biological measures of cognition and stress among adults.
Evidence-based dietary strategies provide behavioral means benefiting physical and cognitive function. Pertinent to the proposed work, dietary intake has been recently shown to have the potential to directly influence the gut microbiota composition as well as brain function. Specifically, the consumption of prebiotics or fibers metabolized by gut bacteria may also play a role. These foods are readily available in the marketplace, however, their implications for physical and cognitive function are not clear. Accordingly, the proposed study aims to investigate effects of prebiotic beverage consumption on changes in behavioral and biological measures of cognition and stress among adults.
University of Illinois at Urbana-Champaign is the lead sponsor of 188 studies on the registry; 29 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
4-5 week period where participant will consume control beverage
Other: Lactose Free 1% Milk
4-5 week period where participant will consume the intervention beverage
Other: Lactose Free 1% Milk + 10 g prebiotic
8 oz of study beverage daily
Also known as: Control
8 oz of study beverage supplemented with 5 grams of fructooligosaccharide and 5 grams of galactooligosaccharide
Biological markers of stress
Changes in 24-hour urinary cortisol, inflammatory markers (e.g. IL-6, CRP).
Time frame: 4-5 weeks
Behavioral markers of stress
Change in reported questionnaire responses specific to depression, stress, and anxiety using the Depression, Anxiety, and Stress (DASS) Questionnaire.
Time frame: 4-5 weeks
Gastrointestinal Microbiota composition
Impact on bacterial genera abundances.
Time frame: 4-5 weeks
Gastrointestinal microbiota beta-diversity
Impact on beta-diversity measures
Time frame: 4-5 weeks
Gastrointestinal Microbiota alpha-diversity
Impact on alpha-diversity measures
Time frame: 4-5 weeks
Cognitive function
Computer tasks will be used to assess working memory, interference control, cognitive flexibility, and hippocampal function/relational memory
Time frame: 4-5 weeks
Sleep
The Pittsburg Sleep Quality Index (PSQI) will also be used to assess sleep, as will actigraphy.
Time frame: 4-5 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University of Illinois at Urbana-Champaign