An observational study in Acute Compartment Syndrome, sponsored by Hebei Medical University Third Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-08-04.
Sponsored by Hebei Medical University Third Hospital · Observational
Acute compartment syndrome (ACS) is defined as a clinical entity originated from trauma or other conditions, and remains challenging to diagnose and treat effectively. Threre is the controversy in diagnosing, treating ACS. It was found that there was no criterion about the ACS, and result unnecessary osteotomy. The presence of clinical assessment (5P) always means the necrosis of muscles and was the most serious or irreversible stage of ACS. Besides pressure methods, the threshold of pressure identifying ACS was also controversial.
32 studies on the registry are indexed under Tibial Plateau Fractures; 12 are open to participants now.
Browse Tibial Plateau Fractures studies →Hebei Medical University Third Hospital is the lead sponsor of 29 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The severe tibial plateau (Ⅴand Ⅵ according to Schatzker's classification) in our hospital who will be treated with open internal fixation in our hospital
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
tibial plateau fractures with blister observed
Procedure: fasciotomy
tibial plateau fractures without blister observed
Procedure: fasciotomy
if it was suspected with ACS, the fasciotomy was conducted. but if the blister observed, it means decreased conmpartment sydrome. therefore, the blister observed can avoid unnecessary fasciotomy to patients suspected with ACS
injury mechanism
The relative data was collected about injury mechanism such as high falling accident, traffic accident, fall from standing height,Crushing
Time frame: up to 1 weeks
the time when the blister appeared
The relative data was collected about the time when the blister appeared after injury
Time frame: up to 4 weeks
time to reconstructive surgery
The relative data was collected about time to reconstructive surgery
Time frame: time to when the surgery was conducted after 2 weeks
union time
The relative data was collected about union time
Time frame: through study completion, an average of 1 year
No non-anatomic gap or step (larger than 5 mm)
The relative data was collected about complications
Time frame: through study completion, an average of 1 year
secondary loss of reduction
The relative data was collected about complications
Time frame: through study completion, an average of 1 year
Deep venous thrombosis
The relative data was collected about complications
Time frame: through study completion, an average of 1 year
superficial wound problems
The relative data was collected about complications
Time frame: through study completion, an average of 1 year
blister skin immunochemistry and immunofluorescence analysis
CK1, 5, 10, claudin 1, 2 and occludin as determined by immunochemistry analysis, and skin barrier proteins; claudin 1, 2 and occludin was determined by immunofluorescence analysis and qPCR.
Time frame: through study completion, an average of 1 year
CK levels
CK levels
Time frame: through hospitalization completion, an average of 1 month
chloride levels
chloride levels
Time frame: through hospitalization completion, an average of 1 month
UREA levels
UREA levels
Time frame: through hospitalization completion, an average of 1 month
LKS score
Lysholm knee score
Time frame: through study completion, an average of 1 year
VAS scores
visual analogue scale
Time frame: through study completion, an average of 1 year
Plan to share: Yes — acute compartment syndrome
Supporting information: Study protocol
Time frame: 2 years after the experiment was conducted
Access criteria: all authors focusing on ACS research
Started Jan 2019 (actual). Primary completion is estimated for Sep 2022, 44 months after the start.
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Hebei Medical University Third Hospital