An observational study in Diaphragm Injury, Phrenic Nerve Paralysis and Thoracic Cancer, sponsored by Aarhus University Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2022-11-01.
Sponsored by Aarhus University Hospital · Observational
This study aims to measure diaphragmatic dysfunction with ultrasonography and nerve stimulation of the phrenicus nerve, in patients undergoing thoracic surgery for lung and esophageal cancer, and correlate measures of diaphramatic function to clinical postoperative endpoints.
750 studies on the registry are indexed under Paralysis; 133 are open to participants now.
This study's enrollment of 40 is below the median of 60 across 199 observational studies indexed under Paralysis.
Browse Paralysis studies →Aarhus University Hospital is the lead sponsor of 289 studies on the registry; 79 are open to participants now.
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Patients scheduled for resection surgeries for either lung or esophagus cancer.
Exclusion Criteria:
Procedure: Lung lobectomy OR esophagus cancer resection
Lunge lobectomy (total) Resection of esophagus cancer
Change in excursion of the diaphragm
Ultrasonographic measure with M-mode of Diaphragmatic Excursion on right hemidiaphragm
Time frame: Prior to surgery to 14 days after surgery
Ultrasonographic measure of the difference in Intrathoracic Area
Intrathoracic Area is measured at inspiration and expiration to calculate the difference in Intrathoracic Area during breathing
Time frame: Prior to surgery to 14 days after surgery
Change in Diaphragmatic Thickening Fraction
Ultrasonographic measurement
Time frame: Prior to surgery to 14 days after surgery
Change in Intercostal Muscle Thickening Fraction
Ultrasonographic measurement
Time frame: Prior to surgery to 14 days after surgery
Change in forced expired volume within the first second (FEV1)
Spirometry
Time frame: Prior to surgery to 14 days after surgery
Change in forced vital capacity (FEV)
Spirometry
Time frame: Prior to surgery to 14 days after surgery
Change in peak flow
Spirometry
Time frame: Prior to surgery to 14 days after surgery
Change in Electromyographic measure of Maximal Diaphragmatic Response after stimulating the phrenic nerve
Time frame: Prior to surgery to 14 days after surgery
Change in Electromyographic measure of Latency of Diaphragmatic Response after stimulating the phrenic nerve
Time frame: Prior to surgery to 14 days after surgery
Change in 6 Minutes Walk Test
Maximum Walking Distance within 6 minutes
Time frame: Prior to surgery to 14 days after surgery
Change in visual analogue scale score
Scoring system for subjective sensation of pain ranging from 0 to 10. Higher numbers signify higher pain sensations
Time frame: Prior to surgery to 14 days after surgery
Accumulated Opiod Use after Surgery
Morphine equivalents
Time frame: Prior to surgery to 14 days after surgery
Postoperative Pulmonary Complications
Comprising: 1. Pneumonia 2. Atelectasis 3. Bronchospasm 4. Hypoxemia 5. Severe Hypoxemia 6. Pleural Effusion 1 \> cm 7. Pneumothorax 8. CPAP or NIV required after 1. postoperative day
Time frame: Prior to surgery to 30 days after surgery
Admission days at the Intensive Care Unit after Surgery
Time frame: Prior to surgery to 60 days after surgery
Number of Admissions after Discharge from the Surgical Department
Time frame: Prior to surgery to 60 days after surgery
Accumulated Admission Days at any Hospital
Time frame: Prior to surgery to 60 days after surgery
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2022. You cannot join it, but the record below documents what was studied.
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Aarhus University Hospital