An observational study in Biliary Atresia, sponsored by Tongji Hospital. Status unknown. Open to participants aged Up to 90 Days. Per ClinicalTrials.gov, last updated 2020-08-10.
Sponsored by Tongji Hospital · Observational
In most babies with biliary atresia (BA) bile ducts on the inside and outside of the liver are affected eventually leading to a complete blockage of bile flow from the liver. This in turn causes scarring (fibrosis) in the liver. The surgery called the Kasai procedure and eventually, a liver transplant could treat biliary atresia. However, children with BA have poor liver function, poor renal reserve, and poor ability to regulate water and electrolytes. Therefore, A reasonable and effective perioperative fluid management is more significant. Considering the high chlorine of saline, the liver burden of Lactated Ringer's solution and Acetated Ringer's solution, the Bicarbonate Ringer's solution which composition is similar to plasma, could be the best choice for perioperative fluid management of BA children. Therefore, we hypothesize that compared with other crystalloids, Bicarbonate Ringer's solution is a better choice to maintain water, electrolyte and acid-base balance in BA children.
75 studies on the registry are indexed under Biliary Atresia; 25 are open to participants now.
This study's planned enrollment of 110 is below the median of 126 across 31 observational studies indexed under Biliary Atresia.
Browse Biliary Atresia studies →Tongji Hospital is the lead sponsor of 373 studies on the registry; 204 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Study Population was diagnosed with biliary atresia, who need Intravenous infusion.
Exclusion Criteria:
According to the choices of the patients' immediate family members, patients will be divided into Bicarbonate Ringer's Solution. drug dosage form: Solution, Intravenous infusion. the drug dosage frequency and duration were no intervention
Drug: Bicarbonate Ringer's solution
According to the choices of patients' immediate family members, patients will be divided into Other Crystalloid. drug dosage form: Solution, Intravenous infusion. the drug dosage frequency and duration were no intervention
Drug: Other Crystalloid
According to the choices of the patients' immediate family members, patients will be divided into Bicarbonate Ringer's Solution. no Intervention.
According to the choices of the patients' immediate family members, patients will be divided into other clinical used crystalloid. no Intervention.
Arterial blood gas changes
Compared with the baseline, the patient's base excess and pH changes at the operation 1h, operation 2h, and the end of the operation.
Time frame: 1 day
Intraoperative dosage of sodium bicarbonate injection
Patients with acidosis during the operation needs to be corrected with sodium bicarbonate injection. We collect the amount of sodium bicarbonate injection used to correct metabolic acidosis during the operation
Time frame: 1 day
Chlorine concentration
We collected the concentration of chloride ion in the patient's blood and urine during the baseline, the operation and three days after operation
Time frame: 3 days
No study locations are listed for this record.
This study is status unknown, as verified in Aug 2020. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Tongji Hospital