An Early Phase 1 interventional study of Control Test and Dexmedetomidine in Spermatic Cord Block, sponsored by Cairo University. Completed at 1 site in Egypt. Open to male participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-04-01.
Sponsored by Cairo University · Early Phase 1, Interventional, and Diagnostic
Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as Dexmetedomidine (Dex), and magnesium.
The technique of the spermatic cord block was first described in the 1960s by Earle AS.Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as Dexmetedomidine (Dex), and magnesium.
Cairo University is the lead sponsor of 4,907 studies on the registry; 1,445 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Drug: Control Test
Drug: Dexmedetomidine
Drug: magnesium sulphate
Drug: Dexmedetomidine and magnesium sulphate
Spermatic cord block by18ml levobupivacaine 0.5% plus 2 ml normal saline in total volume of 20 ml. The procedure is repeated on the contralateral side.
Spermatic cord block by total of 18ml levobupivacaine 0.5% plus 1 μg/kg dexmedetomidine in 2 ml in total volume of 20 ml The procedure is repeated on the contralateral side.
Drug pages: Dexmedetomidine · Magnesium Sulfate
Spermatic cord block by total of 18ml levobupivacaine 0.5% plus 1 μg/kg dexmedetomidine and 100 mg magnesium sulphate in 2 ml in total volume of 20 ml . The procedure is repeated on the contralateral side.
Spermatic cord block by total of 18ml levobupivacaine 0.5% plus 100 mg magnesium sulphate in 2 ml in total volume of 20 ml
Time from injection of LA to the first postoperative analgesic request
(duration of the block).
Time frame: UP TO 1 HOURE
heart rate
beat/min
Time frame: up to 24 hours
VAS
0 No Pain 1-3 Mild Pain (nagging, annoying, interfering little with ADLs) 4-6 Moderate Pain (interferes significantly with ADLs) 7-10 Severe Pain (disabling; unable to perform ADLs)
Time frame: up to 24 hours
perform SCAB
The mean time needed to perform SCAB
Time frame: UP TO 1 HOURE
total nalbuphine consumption
total nalbuphine consumption
Time frame: up to 24 hours
Incidence of complications
complications
Time frame: up to 24 hours
mean arterial blood pressure
mmHg
Time frame: up to 24 hours
Plan to share: Undecided — still working
No publications or documents are linked to this record.
Ran from Jun 2020 to primary completion in Sep 2021, 14 months.
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This study is completed, as verified in Mar 2022. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Dexmedetomidine · Magnesium Sulfate