An observational study in Genetic Predisposition, SDH Gene Mutation and Environmental Exposure, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-08.
Sponsored by Assistance Publique - Hôpitaux de Paris · Observational
The main objective of the pilot phase of PGLEXPO will be to assess the faisability and to precise methodology of a case-control study designed for testing the impact of environmental and professional exposures on the tumoral risk in SDHx-mutation carriers
The main objective of the pilot phase of PGLEXPO will be to assess the faisability and to precise methodology of a case-control study designed for testing the impact of environmental and professional exposures on the tumoral risk in SDHx-mutation carriers.
Patients will be selected from subjects with a mutation in one of the SDHx genes. The cases will have developed a tumor, while the controls will be tumor-free. Controls will be matched to the cases according to sex, age and type of gene affected. Past exposures will be sought through a telephone questionnaire.
235 studies on the registry are indexed under Genetic Predisposition to Disease; 94 are open to participants now.
This study's enrollment of 101 is below the median of 400 across 154 observational studies indexed under Genetic Predisposition to Disease.
Browse Genetic Predisposition to Disease studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
50 cases and 50 controls will be enrolled in a single referral center where they are regurlarly managed and followed for a SDHx-related tumor risk. They will be matched on their date of birth
Exclusion Criteria:
Incapacity to exercise free and informed consent for the study
Feasability of the protocol of a national case/control study (PGL.EXPO2)
Successful pairing of 50 cases with 50 controls
Time frame: 2 years
Feasibility of matching cases and controls
Proportion of cases for which a control could be identified
Time frame: 2 years
Ease of matching cases and controls
Mean number of controls matching for a case
Time frame: 2 years
Plan to share: Yes — Individual participant data (IPD) that underlie results in publication could be shared.
Supporting information: Study protocol
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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