A Phase 2/3 interventional study of Triamcinolone and Methylprednisolone in Major Abdominal Surgery, sponsored by ghada fouad. Completed at 1 site in Egypt. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2021-03-03.
Sponsored by ghada fouad · Phase 2/3, Interventional, and Prevention
In the current Study we will compare between triamcinolone and methylprednisolone as an additive to bupivacaine drug in ultrasound guided TAP block in major open abdominal surgery .
Postoperative pain is one of the main causes of respiratory function derangement after abdominal surgery .Transversus abdominis plane (TAP) block is widely used in abdominal surgery for postoperative analgesia The transversus abdominis plane (TAP) block is aperipheral nerve block that involves the injection of alocal anesthetic (LA) in the plane between the internaloblique and transversus abdominis muscle layers, with the aim of anesthetizing the intercostal nerves supplyingthe abdominal wall (from T6 to L1) By blocking intercostal nerves T6 to L1, TAPblock efficiently blocks somatic pain after abdominalwall surgery
. It providesadequate postoperative pain relief following various abdominal surgeries TAP block can reduce pain scores, opioid consumption, and the incidence of opioid-related complications after abdominal surgery.
The duration of the TAP block is limited to theeffect of the administered LAs. Various adjuvantmedications have been added to the LA to prolong theduration of TAP block and magnify its effects .
Perineural injection of steroids is reported to influence postoperative analgesia.
As a synthetic glucocorticoid, triamcinolone acetonide binds to and activates the glucocorticoid receptor to produce anti-inflammatory responses,such as down-regulating pro-inflammatory cytokine expression , preventing prostaglandin and leukotriene synthesis and release of arachidonic acid, and activating anti-inflammatory transcription factors such as lipocortins
ghada fouad is the lead sponsor of 3 studies on the registry; none are open to participants now.
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Exclusion Criteria:
28 Patients will receive 18 ml of bupivacaine 0.5 % plus 1ml 0.9% saline in TAP block divided equally on both sides
Drug: bupivacaine
28 Patient will receive 18 ml of bupivacaine 0.5 % plus (20 mg of triamcinolone in 1ml 0.9% saline divided equally on both sides in TAP block
Drug: Triamcinolone · Drug: bupivacaine
28 Patient will receive 18 ml of bupivacaine 0.5 % plus (40 mg of methylprednisolone in 1ml 0.9% saline ) on both sides in TAP block.
Drug: Methylprednisolone · Drug: bupivacaine
transversus abdominis plane block with bupivacain and triamicinolone
transversus abdominis plane block with bupivacaine and methylprednisolone
transversus abdominis plane block with bupivacaine alone
analgesic effect of Triamcinolone and Methylprednisolone In Ultrasound Guided Transversus Abdominis Plane Block ( Tap Block ).
visual analogue scale for assessement of pain from 0 to 10 is used where 0 is no pain and 10 is maximum pain
Time frame: 24 hours after surgery
occurance of complication
nausea vomiting hemodynamic changes
Time frame: 24 hours after surgery
Plan to share: No
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This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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