An interventional study of Ketamine 0.3 mg/kg at end-of-surgery and Ketamine 0.3 mg/kg at anesthesia induction in General Anesthesia, Laparotomy and Inflammation, sponsored by Udayana University. Completed at 1 site in Indonesia. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2020-11-12.
Sponsored by Udayana University · Not applicable, Interventional, and Supportive care
The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was found that nociception and proinflammatory cytokines play a joint regulatory role, i.e., increased production of proinflammatory cytokines can worsen the pain. Major surgery can trigger the release of cytokines such as IL-1, IL-6, and TNF-α.
The effects of anesthesia and surgery can lead to stress responses that result in hormonal and metabolic changes in the body. The immune system and the nervous system communicate both ways, and it was found that nociception and proinflammatory cytokines play a joint regulatory role, i.e., increased production of proinflammatory cytokines can worsen the pain. Major surgery can trigger the release of cytokines such as IL-1, IL-6, and TNF-α.
The acute analgesic effect of ketamine is generally believed to be mediated through the blockade of the phencyclidine binding site of the N-methyl-d-aspartate (NMDA) receptor of nociceptive neurons. Ketamine can reduce the inflammatory response marked by a decrease in CRP levels to surgical trauma and can prevent secondary damage to tissues/organs that were not initially affected by surgery by reducing inflammation. This also reduces postoperative pain and analgesics.
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This study's enrollment of 68 is above the median of 50 across 2,437 interventional studies indexed under Inflammation.
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Exclusion Criteria:
Drop Out Criteria
Low-dose ketamine (0.3 mg/kg) in 3 ml normal saline solution given at the end of surgery
Drug: Ketamine 0.3 mg/kg at end-of-surgery · Drug: Ketamine 0.3 mg/kg at anesthesia induction
Low-dose ketamine (0.3 mg/kg) in 3 ml normal saline solution given at induction
Drug: Ketamine 0.3 mg/kg at end-of-surgery · Drug: Ketamine 0.3 mg/kg at anesthesia induction
Ketamine 0.3 mg/kg at end-of-surgery (intravenously)
Also known as: Group E
Ketamine 0.3 mg/kg at anesthesia induction (intravenously)
Also known as: Group I
Serum CRP level
Serum C-reactive protein level
Time frame: 1-hour before surgery
Serum CRP level
Serum C-reactive protein level
Time frame: 24-hours after surgery
serum neutrophil-count
serum neutrophil-count (from a complete blood count test)
Time frame: 1-hour before surgery
serum neutrophil-count
serum neutrophil-count (from a complete blood count test)
Time frame: 24-hours after surgery
VAS (visual analog score)
minimum=0; maximum=10; higher score corresponds to more severe pain
Time frame: first 24 hours after the surgery
morphine consumption (mg)
total morphine consumption in 24 hours after the surgery
Time frame: first 24 hours after the surgery
Plan to share: No
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This study is completed, as verified in Nov 2020. You cannot join it, but the record below documents what was studied.
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