An observational study in Syphilis Acquired and Syphilis Infection, sponsored by Hospital de Niños R. Gutierrez de Buenos Aires. Completed at 1 site in Argentina. Open to participants aged 0 Years to 18 Years. Per ClinicalTrials.gov, last updated 2023-03-01.
Sponsored by Hospital de Niños R. Gutierrez de Buenos Aires · Observational
Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always considered and must be ruled out by specialists in a careful evaluation.
However, muco-cutaneous lesions can be a contagious source for congenital syphilis; therefore the possibility of non-sexual transmission through intimate contact with infected people through humid lesions (such as in kisses, breastfeeding, food-handling) or contaminated fomites (towels, bed sheets, underwear, cups, pacifiers, cutlery) could be considered. Experts worldwide have observed this non-sexual transmission, as described in many reports in literature.
The investigators will study retrospectively patients from a cohort with non-sexual transmission. The diagnosis criteria used for acquired syphilis were as follows: age under 18 years with treponemic and nontreponemic positive tests, secondary-syphilis suspicious lesions and negative maternal syphilis serology. Nonsexual contagious was defined as contacts without physical and psychosocial indicators of sexual abuse according to current guides. In this cohort, in every case a psychosocial evaluation was completed with a written report in order to evaluate sexual contact probability.
The teamo will describe these patients clinical and laboratory findings, family and close acquaintances serologies and probable source of contagious.
Children from 0 to 18 years of age assisted at Parasitoloy and Chagas department from Children's Hospital in Buenos Aires, Argentina
EXCLUSION CRITERIA:
Describe diagnose process of a cohort of children with assumed non-sexual acquired syphilis
Describe the interdisciplinary approach of patients with acquired syphilis and how non-sexual transmission was assumed
Time frame: Past 20 years
Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts
Investigators will report serology titers from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening
Time frame: Past 20 years
Describe reported symptoms and physical findings at diagnose and during follow-up f children with assumed non-sexual acquired syphilis and their close contacts
Investigators will describe symptoms and physical findings from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening
Time frame: Past 20 years
This study is completed, as verified in Feb 2023. You cannot join it, but the record below documents what was studied.
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Hospital de Niños R. Gutierrez de Buenos Aires