An observational study in Lynch Syndrome, sponsored by University Hospital, Lille. Completed at 1 site in France. Open to female participants aged 30 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-03-09.
Sponsored by University Hospital, Lille · Observational
Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome.
Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen.
Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.
1,325 studies on the registry are indexed under Endometrial Neoplasms; 446 are open to participants now.
This study's enrollment of 150 is below the median of 179 across 321 observational studies indexed under Endometrial Neoplasms.
Browse Endometrial Neoplasms studies →University Hospital, Lille is the lead sponsor of 625 studies on the registry; 141 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Women included are all carriers of Lynch syndrome, already diagnosed by genetic analysis in the Molecular Biology Laboratory of the CHU de Lille and whose analysis was transmitted during a consultation at the Guy Fontaine Genetics Clinic during the period from 01/01/1998 to 30/11/2019 at the CHU de Lille or in advanced consultations in the regions.The database PROGENY will be use to extract population corresponding to the study
Case group :
Control group :
Exclusion Criteria:
Women with Lynch Syndrome and endometrial Cancer matched on age of endometrial cancer diagnosis
Other: questionnaire assesment
Women with Lynch Syndrome, without Cancer at Lynch Syndrome Diagnostic matched on their age at Lynch Diagnostic
Other: questionnaire assesment
Each patient will to answer questions about their medical history.
Correlation between endometrial cancer and predictif factors
Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use.
Time frame: Baseline
Correlation between endometrial cancer and predictif factors in post menopausal woman
Endometrial cancer (yes/no) and explicative variable: Menopause age; Hormonal menopause treatment
Time frame: Baseline
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2021. You cannot join it, but the record below documents what was studied.
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University Hospital, Lille