An observational study in Obesity, Childhood and Metabolic Syndrome, sponsored by Federico II University. Status unknown at 1 site in Italy. Open to participants aged 10 Years to 16 Years. Per ClinicalTrials.gov, last updated 2020-07-07.
Sponsored by Federico II University · Observational
Pediatric obesity is a risk factor for the onset of obesity in adulthood and is a risk factor for various chronic non-communicable diseases. Metabolic syndrome (MS) is the name for a group of risk factors that increase cardiovascular risk and other health problems characterized by the presence of abdominal obesity, dyslipidemia, hyperglycaemia and high blood pressure. Numerous preclinical and clinical data suggest a potential role of the intestinal microbiota in these diseaes. Unfortunately, comparative studies of the gut microbiota are still scarce in pediatric subjects suffering from obesity than obesity complicated by MS. The aim is to study the metagenomics and metabolomics characteristics of the intestinal microbiota in obese children/adolescents with or without MS, that could provide useful data for innovative intervention strategies for these conditions.
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's planned enrollment of 120 is below the median of 135 across 1,283 observational studies indexed under Obesity.
Browse Obesity studies →Federico II University is the lead sponsor of 356 studies on the registry; 60 are open to participants now.
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Children/adolescents of both sexes, aged between 10-16 years, with obesity, obesity complicated by metabolic syndrome and healthy controls observed at Pediatrics Section of Department of Translational Medical Sciences (University of Naples Federico II)
Exclusion Criteria:
Subjects with obesity
Other: Obese with or without metabolic syndromesubjects
Subjects with obesity and metabolic syndrome
Other: Obese with or without metabolic syndromesubjects
Otherwise healthy subjects
Children with obesity and with or without metabolic syndrome
Concentration of metagenomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls
Evaluation of gut microbiota composition
Time frame: at enrollment
Concentration of metabolomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls
Evaluation of butyrate
Time frame: at enrollment
Concentration of the metabolomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls
Evaluation of acetate
Time frame: at enrollment
Concentration of the metabolomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls
Evaluation of propionate
Time frame: at enrollment
Concentration of the metabolomic characteristics of the intestinal microbiota in subjects with obesity, obesity complicated by metabolic syndrome and healthy controls
Evaluation of indole
Time frame: at enrollment
Plan to share: Undecided
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This study is status unknown, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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Federico II University