An interventional study of Neurofeedback in Mild Cognitive Impairment, sponsored by VA Office of Research and Development. Completed at 1 site in United States. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-10-20.
Sponsored by VA Office of Research and Development · Not applicable, Interventional, and Treatment
Military deployment is associated with increased risk of mild cognitive impairment (MCI). Combat stress related memory deficits has been well documented. Mild cognitive impairment such as memory deficits are the most common and earliest symptoms of Alzheimer's disease and related dementia (ADRD). The complaints about declined memory are common in healthy and cognitively intact civilian older adults, but less understood in aging Veterans. Brain training strategies to enhance cognitive skills and especially memory processes are unmet needs in aging Veterans who are at additional risk for MCI induced by ADRD. Since currently there is no effective drug treatment to stop cognitive decline, non-invasive brain training to boost memory functions in older Veterans is an increasingly attractive option to attenuating decline in memory.
The proposed project is poised to investigate state-of-art neurofeedback (NF; biofeedback of brain activity) training for self-modulation of neural plasticity to boost memory performance in Veterans. The recent advance of NF with Brian-Computer Interface (BCI) has provided a novel way to examine brain functions and plasticity. Thus far, there have been limited applications that have developed effective experimental and clinical paradigms for rehabilitation in Veterans. Historically, brainwave patterns during memory task performance have been analysed offline, a methodology which does not allow real-time NF modulation and training. The central hypothesis guiding this research is that optimal memory-related brainwave patterns of a Veteran can be trained. The online NF allows maximization of brainwave patterns associated with healthier memory states.
The development of efficient NF paradigms to augment memory performance is an important first step for the application of this nonpharmacologic intervention to improve combat Veterans' memory functions and potential for treating MCI due to mild TBI or pain. The pilot work will start with wider range of Veterans using state-of-the-art wearable wireless brain-computer interface headset, which is affordable and can be easily set up in VAMCs and eventually in remote assessment settings. This innovative, cognitive neuroscience based, nonpharmacologic intervention serves to revolutionize the diagnosis and treatment of combat Veterans who are at risk for degenerative dementia.
3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's enrollment of 4 is below the median of 65 across 2,808 interventional studies indexed under Cognitive Dysfunction.
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Of its 206 completed or terminated interventional studies of FDA-regulated products, 180 (87%) have results posted.
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Exclusion Criteria:
Vets with mild cognitive impairment
Device: Neurofeedback
Normal healthy Veterans
Device: Neurofeedback
Neurofeedback will be tested in both groups of Vets
Also known as: biofeedback
EEG alpha band
alpha power under eyes closed and eyes open are linked to better mental state; likely biomarker for mild cognitive impairment.
Time frame: 6-8 weeks
memory-related potentials
Brainwaves that are linked to better memory performance
Time frame: 6-8 weeks
California Verbal Learning Test
A battery of neuropsychological testing cognitive functions
Time frame: About 6-8 weeks
Documents are hosted by the registry — open the source record to download them.
Plan to share: No — De-identified data will be analyzed and kept at least 6 years after project. Results will be shared via publications. The qualified researchers may contact PI and VA for further sharing of the research data.
This study is completed, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.
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VA Office of Research and Development