CClinicalTrials.gg
Status unknownNCT04434963Updated Sep 14, 2021

Safety and Feasibility of Reversible Induction Strategy

An observational study in Patients With Uncertain Difficult Airway, Colon Cancer and Gastric Cancer, sponsored by RenJi Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2021-09-14.

Sponsored by RenJi Hospital · Observational

The sponsor has not verified this record recently (last verified Sep 2021), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
20
Ages
18 Years to 65 Years
Sex
All
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Study summary

This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term effect anesthetic including Propofol and Remifentanil for sedation and analgesia and Sugammadex would be used for reverse the muscle relaxant.

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Conditions studied

  • Patients With Uncertain Difficult Airway
  • Colon Cancer
  • Gastric Cancer
  • Prostatic Cancer

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Keywords

  • THRIVE
  • Uncertain difficult airway
  • Reversible induction strategy
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In context

Prostatic Neoplasms

6,367 studies on the registry are indexed under Prostatic Neoplasms; 1,397 are open to participants now.

This study's planned enrollment of 20 is below the median of 200 across 1,179 observational studies indexed under Prostatic Neoplasms.

Browse Prostatic Neoplasms studies →

Lead sponsor

RenJi Hospital is the lead sponsor of 535 studies on the registry; 244 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with an uncertain difficult airway, who will undergo a selective operation and need trachea intubtion.

Inclusion criteria

  • >18 years old,\<65 years old
  • Signed informed consent
  • Undergoing selective operation ( time of operation is over two hours)
  • ASA classification I-II
  • Mallampati classification 3-4
  • suspicious difficult airway, but the anesthetists decide to try to rapid induction

Exclusion criteria

Exclusion Criteria:

  • Patients with several dysfunctions of liver, kidney or heart)
  • Patients with a full stomach or have other risk factors of reflux aspiration
  • Any medicine was taken before surgery, which might enhance or mitigate the effects of muscle relaxant
  • Infection of the mouth or nose
  • Allergy history of any medicine which would be used in this study
  • Pregnant and lactating women
  • Patients with neuromuscular disease
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
20 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Successful rate of reversion

    Time frame: From the beginning of induction to 15min later

Secondary outcomes

  1. TOFr 0.9 reversion time

    Time frame: From the beginning of induction to 15min later

  2. BIS 80 reversion time

    Time frame: From the beginning of induction to 15min later

  3. Tidal volume 6-8ml tidal volume 6-8ml/kg reversion time

    Time frame: From the beginning of induction to 15min later

  4. consciousness reversion time

    Time frame: From the beginning of induction to 15min later

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Study locations

1 of 1 sites recruiting
  • Ren Ji Hospital Affliated to School of Medicine, Shanghai Jiao Tong University
    Shanghai, Shanghai 200127, China
    Recruiting
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References and documents

Individual participant data

Plan to share: No — IPD is unavailable to other researchers

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 14, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04434963
Lead sponsor
RenJi Hospital
Responsible party
diansan su (Principal Investigator, RenJi Hospital) — Principal investigator
First posted
Jun 17, 2020
Start date
Feb 1, 2021
Primary completion
Dec 1, 2021 (estimated)
Completion
Dec 1, 2021 (estimated)
Last update
Sep 14, 2021

Study contacts

diansan su
Contact
diansansu@yahoo.com
+862168383702
Xiaoying Chi, M.S.
Contact
chixiaoying@renji.com
+86 18201706040
diansan su
study director · Renji Hospital, Shanghai Jiaotong University, Shanghai, China

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.

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