An observational study in Perforated Diverticulitis, sponsored by Sahlgrenska University Hospital. Active, not recruiting at 1 site in Sweden. Per ClinicalTrials.gov, last updated 2026-04-27.
Sponsored by Sahlgrenska University Hospital · Observational
Perforated diverticulitis of the colon can be complicated by peritonitis, either purulent or fecal. Both are life threatening conditions requiring emergency surgery. The background in terms of reasons for inflammation (diverticulitis) and perforation to develop is unknown. In this study we focus on specific changes associated with inflammation, both in tissues and of fecal and mucosal microbiota.
A prospective study of abdominal fluid, periferal blood, tissues as well as feces in Patients (perforated diverticulitis with peritonitis undergoing emergency surgery, Group I), and in Controls (patients operated due to colorectal cancer, Group II; patients with mild diverticulitis not needing surgery, Group III).
Immune acitvity in abdominal fluid and periferal blood by immunoassay of 92 individual proteins. mRNA expression of 96 specific genes in tissue samples. Quatification of bacterial diversity in feces and colon mucosa.
167 studies on the registry are indexed under Peritonitis; 23 are open to participants now.
This study's planned enrollment of 50 is below the median of 137 across 55 observational studies indexed under Peritonitis.
Browse Peritonitis studies →Sahlgrenska University Hospital is the lead sponsor of 263 studies on the registry; 68 are open to participants now.
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The aim is to study immune responses in patients with perforated divrticulitis leading to peritonitis and emergency surgery. This group will be compared with patients operated for colorectal cancer and patients with uncomplicated (mild) diverticulitis not undergoing surgery.
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Exclusion Criteria:
Patients undergoing emergency surgery due to perforated diverticulitis with peritonitis. No intervention, samples from abdominal fluid, blood, tissue, feces
Patients with colorectal cancer undergoing elective surgery. No intervention. Samples as for Group I
Patients with mild diverticulitis, not undergoing surgery. No intervention. Samples from blood and feces.
inflammatory response
determination of levels of 92 proteins in abdominal fluid and blood
Time frame: index surgery (Groups I and II)/ emergency room (Group III)
inflammatory response in tissue
RNA sequencing (96 spcific genes) in abdominal tissue
Time frame: index surgery (Groups I and II)/ emergency room (Group III)
microbiota composition
PCR amplification, cloning and sequencing of genes
Time frame: index surgery (Groups I and II)/ emergency room (Group III)
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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