An observational study in Genetic Predisposition to Disease, sponsored by The Institute of Molecular and Translational Medicine, Czech Republic. Recruiting at 1 site in Czechia. Open to participants aged 18 Years to 68 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-13.
Sponsored by The Institute of Molecular and Translational Medicine, Czech Republic · Observational
This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population and will evaluate its correlation with the disease phenotype.
This study will determine reference genomic, transcriptomic, proteomic and metabolomic profiles in Czech population. Initially, there will be 1000 healthy volunteers, with the planned expansion to 10.000 participants (healthy volunteers and patients with different types of disease). Formation of the reference database of healthy volunteers and their parameters will allow a correct interpretation of the potential pathological findings in patients. It is very important to obtain healthy controls from the region of the Czech Republic, Central Europe respectively; since it is not possible to reliably compere ethnically and geographically diverse populations, which have generated in a different context and where the diseases manifest with other etiology ad phenotype. Although, in the limited measure, the similar molecular data exist in foreign databases, these are not compiled from the inhabitants of the Czech Republic, Central Europe not even from Slavic population. Study participants may volunteer for archiving of remaining biological materials for future studies.
235 studies on the registry are indexed under Genetic Predisposition to Disease; 94 are open to participants now.
This study's planned enrollment of 1,100 is above the median of 400 across 154 observational studies indexed under Genetic Predisposition to Disease.
Browse Genetic Predisposition to Disease studies →The Institute of Molecular and Translational Medicine, Czech Republic is the lead sponsor of 18 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Selection from the blood donnors from the blood transfusion department.
Exclusion Criteria:
Determination of genomic, transcriptomic, proteomic, metabolomic profiles in subjects.
Genetic: Blood sample analysis · Other: Health status · Other: Race and ethnicity
Nucleic acids sequencing, presence of proteins and metabolites.
Health status will be examined by a physician and subject will complete a health status questionnaire.
Subject will complete race and ethnicity questionnaire to make sure subjects are from the Czech population.
Whole Genome (Exom) Sequencing of the Healthy Volunteers - establishment of the HEALTHY VOLUNTEER REFERENCE GENOME (min. 1000 individuals)
Establishment of the Healthy Volunteers Whole Genome (Exom) Reference Database typical for the population of the Czech Republic/Central Europe.
Time frame: 72 months
Whole Genome (Exom) Sequencing of the patient groups with different diseases and their comparison to the HEALTHY VOLUNTEER REFERENCE GENOME
Whole Genome (Exom) Sequencing of the patient populations presenting various diseases. Based on the comparison with the HEALTHY VOLUNTEER REFERENCE GENOME - determination of various genetic polymorphisms (single nucleotide polymorphisms, insertions, deletions, inversions, copy-number variations etc.) and giving these into correlation with disease phenotypes.
Time frame: 72 months
Evaluation of the correlation with the disease phenotype
Based on the reference database of healthy volunteers in the Czech Republic a potential correlations will be evaluated among genomic, proteomic and metabolomic profiles of patients and the disease phenotypes.
Time frame: 72 months
Plan to share: No
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Genetic Predisposition to Disease→
The Institute of Molecular and Translational Medicine, Czech Republic