An observational study in Infertility, Infertility, Female and IVF, sponsored by ART Fertility Clinics LLC. Completed at 1 site in United Arab Emirates. Open to female participants aged 18 Years to 42 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-02-18.
Sponsored by ART Fertility Clinics LLC · Observational
This study will determine the rise of progesterone levels after human chorionic gonadotrophin (hCG) trigger in stimulated cycles IVF/ICSI
Studies have suggested that controlled ovarian hyperstimulation adversely affects endometrial receptivity. In ovarian stimulation cycles with exogenous gonadotrophins there is an ongoing debate regarding the effect of a late follicular phase progesterone level on reproductive outcomes. It is not yet clarified if an elevated serum progesterone level in the late follicular phase is a symptom or cause of an adverse effect on reproductive outcomes. A new hypothesis is evolving and gaining momentum providing a novel explanation for the association between late follicular phase progesterone rise and reproductive outcome. It is proposed that exogenous FSH (Follicle-stimulating hormone) administration results in supraphysiological levels of FSH, which induce an abundance of LH (luteinizing hormone) receptors on granulosa cells causing the follicles to become hypersensitive to LH-like activity (ie hCG trigger). Based on this hypothesis, the focus should be placed on the hCG trigger rather than on the late follicular phase progesterone rise.
2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.
This study's enrollment of 10 is below the median of 200 across 714 observational studies indexed under Infertility.
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Female patients who are planned to commence ovarian stimulation for IVF/ICSI with hCG trigger for oocyte maturation and plan to avail of pre-implantation genetic screening with embryo vitrification of their biopsied embryos at blastocyst stage
Exclusion Criteria:
Patients will have blood drawn on five separate occasions: before and following hCG trigger on the day of final oocyte maturation and day of egg collection
Drug: hCG · Diagnostic Test: Ultrasound · Other: Blood test
human chorionic gonadotropin
Also known as: human chorionic gonadotropin
Endometrial thickness monitoring
Also known as: transvaginal scan
Progesterone, Luteinizing Hormone, Estradiol
Also known as: Progesterone, Luteinizing Hormone, Estradiol
Level of progesterone day of trigger
day of the hCG trigger between 1000h - 1200h, before trigger, 1 hour after trigger, 2 hrs after trigger
Time frame: 1 day
Level of progesterone day of egg retrieval
36hrs after trigger
Time frame: 1 day
Plan to share: Undecided
This study is completed, as verified in Feb 2022. You cannot join it, but the record below documents what was studied.
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