An interventional study of Tai Chi Chuan and Fitness Walking in Diabetes Mellitus, Type 2 and Cognitive Dysfunction, sponsored by Jing Tao. Completed at 1 site in China. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2022-09-22.
Sponsored by Jing Tao · Not applicable, Interventional, and Treatment
The patients with type 2 diabetes mellitus (T2DM) is expected to rise to 439 million in 2030, accounting for 7.7% the population in the world. There are nearly 10 million T2DM patients with mild cognitive impairment (MCI) among people over 65 years old , accounting for about 8% of the people over 65 years old in China. The medical cost for patients with T2DM/MCI is 2.5 to 4 times higher than those without T2DM. And T2DM will increase the risk of cognitive impairment, and lead to various complications which will bring serious social and medical economic burden.
It is critically important to identify effective treatments to enhance functional status of T2DM/MCI patients. Exercise has been shown to be beneficial for T2DM/MCI patients. As a Chinese traditional mind-body exercise that consists of both physical and mediation components, Tai Chi Chuan has been proved to be helpful in global cognition, memory, executive function and attention of MCI, and blood sugar of T2DM. However, the evidence of the effect of Tai Chi Chuan on T2DM/MCI patients is limited. The purpose of this study is to explore the effect of Tai Chi Chuan treating T2DM/MCI patients in cognitive function, balance, motor and sensation function, blood sugar, biochemistry profile and quality of life.
10,925 studies on the registry are indexed under Diabetes Mellitus; 1,319 are open to participants now.
This study's enrollment of 328 is above the median of 80 across 8,367 interventional studies indexed under Diabetes Mellitus.
Browse Diabetes Mellitus studies →Jing Tao is the lead sponsor of 3 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour Tai Chi Chuan training per week for 24 weeks and standard diabetic care education.
Behavioral: Tai Chi Chuan
In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour fitness walking training per week for 24 weeks and standard diabetic care education
Behavioral: Fitness Walking
In addition to conventional medical treatment, participants will receive standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
Behavioral: Standard Diabetic Care Education
Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
Participants would take fitness walking training 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes fitness walking and 10 minutes cool-down exercises in the fitness walking training, the exercise intensity was 50% to 70% of the maximum heart rate. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
Participants would take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months.
Global cognition-Montreal Cognitive Assessment at 36 Weeks
Montreal Cognitive Assessment
Time frame: 36 weeks (post-intervention follow-up)
Global cognition-Montreal Cognitive Assessment at 24 weeks
Montreal Cognitive Assessment
Time frame: 24 weeks (post-intervention)
Memory function-Wechsler Memory Scale at 24, 36 Weeks
Wechsler Memory Scale
Time frame: 24, 36 weeks
Digital Symbol test at 24, 36 weeks
Digital Symbol test
Time frame: 24, 36 weeks
Trial Making Test part B at 24, 36 weeks
Trial Making Test part B
Time frame: 24, 36 weeks
Stroop color word test at 24, 36 weeks
Stroop color word test
Time frame: 24, 36 weeks
Boston naming test at 24, 36 weeks
Boston naming test
Time frame: 24, 36 weeks
Rey-Osterrieth complex graphics test at 24, 36 weeks
Rey-Osterrieth complex graphics test
Time frame: 24, 36 weeks
Multi-task balance test: Time up and go test; Time up and go test + cognitive task;Time up and go test + motor task;Time up and go test + cognitive task + motor task at 24, 36 weeks
Time up and go test; Time up and go test + cognitive task (animal naming); Time up and go test + motor task (holding a cup of water); Time up and go test + cognitive task + motor task.
Time frame: 24, 36 weeks
Functional reach test at 24, 36 weeks
Functional reach test
Time frame: 24, 36 weeks
One leg stance test at 24, 36 weeks
One leg stance test
Time frame: 24, 36 weeks
Grip strength at 24, 36 weeks
Grip strength
Time frame: 24, 36 weeks
Five times sit-to-stand test at 24, 36 weeks
Five times sit-to-stand test
Time frame: 24, 36 weeks
Sensation function at 24, 36 weeks
Tactile sensation; Two-point discrimination sensation; Vibration sensation.
Time frame: 24, 36 weeks
Fall efficiency-Modified Falls Efficacy Scale at 24, 36 weeks
Modified Falls Efficacy Scale
Time frame: 24, 36 weeks
Quality of life-Medical Outcomes Study 36-item Short-Form Health Survey at 24, 36 weeks
Medical Outcomes Study 36-item Short-Form Health Survey (SF-36)
Time frame: 24, 36 weeks
Blood glucose metabolism index at 24, 36 weeks
fasting blood glucose; glycosylated hemoglobin; fasting insulin
Time frame: 24, 36 weeks
Blood lipid metabolism index at 24, 36 weeks
total cholesterol (TC); total triglyceride (TG); low density lipoprotein (LDL),;high density lipoprotein (HDL).
Time frame: 24, 36 weeks
Circulating levels of AGE and sRAGE at 24, 36 weeks
Circulating levels of AGE and sRAGE
Time frame: 24, 36 weeks
functional Magnetic Resonance Imaging (fMRI)
functional Magnetic Resonance Imaging
Time frame: baseline, 24 weeks
This study is completed, as verified in Sep 2022. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.