An interventional study of orange juice concentrate and Sugar-sweetened orange-flavoured beverage in Diabetes Mellitus, Type 2, sponsored by Hasselt University. Completed at 1 site in Belgium. Open to participants aged 25 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-05-17.
Sponsored by Hasselt University · Not applicable, Interventional, and Other
The evidence on the consumption of 100% orange juice in people with type 2 diabetes is highly variable and largely out-of-date, with a few studies reporting acute negative glycaemic effects when 100% orange juice is drunk with or without a meal. The aim of the project is to study the impact of the intake of a single serving of 100% orange juice on glycaemic control in male patients with pre-existing type 2 diabetes mellitus. In addition, immunological parameters and Alzheimer disease related biomarkers will be assessed to examine the chronic inflammatory state of these patients
9,589 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,332 are open to participants now.
This study's enrollment of 15 is below the median of 81 across 7,713 interventional studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →Hasselt University is the lead sponsor of 203 studies on the registry; 31 are open to participants now.
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Exclusion Criteria:
orange juice concentrate
Other: orange juice concentrate
Sugar-sweetened orange-flavoured beverage
Other: Sugar-sweetened orange-flavoured beverage
Whole orange juice with skin removed
Other: Whole orange juice with skin removed
250mL of 100% orange juice made from concentrate
Sugar-sweetened orange-flavoured beverage, energy-matched to the orange juice condition
Whole orange pieces with skin removed, energy-matched to the orange juice condition
Glycaemic responses venous blood
Venous blood samples collected to examine systemic glycemia (venous blood glucose concentration (mg/dL)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: baseline
Glycaemic responses venous blood
Venous blood samples collected to examine systemic glycemia (venous blood glucose concentration (mg/dL)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Day 5
Glycaemic responses venous blood
Venous blood samples collected to examine systemic glycemia (venous blood glucose concentration (mg/dL)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Day 10
Insulin responses
Venous blood samples collected to examine systemic insulinemia (venous blood insulin concentration (pmol/L)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Baseline
Insulin responses
Venous blood samples collected to examine systemic insulinemia (venous blood insulin concentration (pmol/L)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Day 5
Insulin responses
Venous blood samples collected to examine systemic insulinemia (venous blood insulin concentration (pmol/L)) before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Day 10
Capillary glycaemic responses
Capillary blood samples collected to examine glycemia before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Baseline
Capillary glycaemic responses
Capillary blood samples collected to examine glycemia before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Day 5
Capillary glycaemic responses
Capillary blood samples collected to examine glycemia before, during and after a breakfast (differing in supplemented juice composition) for up to 5 hours postprandial.
Time frame: Day 10
Glycated haemoglobin measure
Measured on a single blood sample to characterize patients' overall glycaemic contro
Time frame: Baseline
Flow cytometry
Fasting venous blood samples collected to examine Peripheral blood mononuclear cells (flow cytometry) to measure immunological parameters
Time frame: Baseline
Alzheimer disease related biomarkers
Blood samples will be collected every 30 min for 5 hours to examine Alzheimer disease relevant biomarkers (Abeta42, Abeta40, Tau, p-Tau, neuroinflammatory markers and other)
Time frame: Baseline
BMI
body weight/height (to determine BMI)
Time frame: Baseline
Waist/hip circumference (Body composition)
Waist/hip circumference
Time frame: Baseline
Systolic/diastolic blood pressure
Systolic/diastolic blood pressure
Time frame: Baseline
This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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