CClinicalTrials.gg
Status unknownNCT04400916Updated May 26, 2020

Topical Tranexamic Acid After Intravitreal Injections

An interventional study of Tranexamic acid and Balanced Salt Solution in Subconjunctival Hemorrhage, sponsored by Rambam Health Care Campus. Status unknown. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-05-26.

Sponsored by Rambam Health Care Campus · Not applicable, Interventional, and Prevention

The sponsor has not verified this record recently (last verified May 2020), so the status shown — last known as Not yet recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

We aim to investigate whether topical administration of Tranexamic acid can reduce the occurence of subconjunctival hemorrahge after routine intravitreal injections for retinal conditions.

02

Conditions studied

  • Subconjunctival Hemorrhage

Browse trials for

03

In context

Hemorrhage

3,000 studies on the registry are indexed under Hemorrhage; 474 are open to participants now.

This study's planned enrollment of 100 is close to the median of 100 across 1,985 interventional studies indexed under Hemorrhage.

Browse Hemorrhage studies →

Lead sponsor

Rambam Health Care Campus is the lead sponsor of 456 studies on the registry; 33 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

Subjects receiving intravitreal injections as part of their routine ophthalmological care

Exclusion criteria

Exclusion Criteria:

Pregnancy, Oral contraceptives/HRT use, Known systemic autoimmune disease, Renal failure, active/suspected infection or inflammation in the treated eye, subconjunctival hemorrahge prior to inclusion, History of subarachnoid hemorrahge, thromboembolic events, increased risk for thromboembolic events, known sensitivity to the study drug

05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
100 participants (estimated)

Study arms

  • Experimental
    Topical tranexamic acid

    Drug: Tranexamic acid

  • Placebo comparator
    Topical BSS

    Other: Balanced Salt Solution

Interventions

  • DrugTranexamic acid

    A single drop administered topically

  • OtherBalanced Salt Solution

    A single drop administered topically

06

What researchers measure

Primary outcomes

  1. Subconjunctival hemorrahge

    Time frame: 3 days

07

Study locations

No study locations are listed for this record.

08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 26, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04400916
Lead sponsor
Rambam Health Care Campus
Responsible party
Shiri Soudry MD (Attending faculty and vitreoretinal surgeon, Department of Ophthalmology, Rambam Health Care Campus) — Principal investigator
First posted
May 26, 2020
Start date
Sep 2020 (estimated)
Primary completion
Sep 2021 (estimated)
Completion
Dec 2021 (estimated)
Last update
May 26, 2020

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in May 2020. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion