An interventional study of Silver Diamine Fluoride 38% in Root Caries, sponsored by Roseman University of Health Sciences. Completed. Open to participants aged 55 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-30.
Sponsored by Roseman University of Health Sciences · Not applicable, Interventional, and Treatment
The authors conducted a case series to determine the outcomes of treatment of root surface caries lesions when the teeth were treated topically with 38% silver diamine fluoride.
The study is a prospective, single center case series. The cases were consecutive. Participation was offered to every patient who qualified based on age and the presence of an active lesion in a root surfaces, in a furcation, or under an individual crown or crown abutment for a fixed prosthesis. The study was conducted at the dental clinic of the Roseman College of Dental Medicine in South Jordan, Utah. The University of California, San Francisco protocol for applying topical silver diamine fluoride was adapted for use with these patients. Lesions were flushed with water and then dried with compressed air, isolated with cotton rolls, and then 38% silver diamine fluoride (Advantage Arrest, Elevate Oral Care, West Palm Beach, FL) was applied repeatedly for two minutes with the manufacturer supplied dental applicator. The silver diamine fluoride was stored under the manufacturer's recommended conditions. If the patient complained about the taste, the lesion was coated with sodium fluoride varnish. All of the lesions were reevaluated for dental caries lesion activity about every six months and retreated regardless of their arrest status. Follow-up was for 30 months or until loss to follow-up.
39 studies on the registry are indexed under Root Caries; 14 are open to participants now.
This study's enrollment of 63 is close to the median of 62 across 35 interventional studies indexed under Root Caries.
Browse Root Caries studies →Roseman University of Health Sciences is the lead sponsor of 2 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Topical application of one drop of silver diamine fluoride 38% to active untreated roof surface caries, lesions at the furcation, or lesions at crown margins. Application was repeated once each six months.
Device: Silver Diamine Fluoride 38%
Dental caries arrest medication
Also known as: Advantage Silver Arrest
Dental caries lesion activity 1
Nyvad score based on visual/tactile examination
Time frame: 6-12 months
Dental caries lesion activity 2
Nyvad score based on visual/tactile examination
Time frame: <6 months
Dental caries lesion activity 3
Nyvad score based on visual/tactile examination
Time frame: 12-18 months
Dental caries lesion activity 4
Nyvad score based on visual/tactile examination
Time frame: 18-24 months
Dental caries lesion activity 5
Nyvad score based on visual/tactile examination
Time frame: 24-30 months
Caries lesion fluorescence 1
Laser fluorescence measurement at the surface of the lesion
Time frame: <6 months
Caries lesion fluorescence 2
Laser fluorescence measurement at the surface of the lesion
Time frame: 6-12 months
Caries lesion fluorescence 3
Laser fluorescence measurement at the surface of the lesion
Time frame: 12-18 months
Caries lesion fluorescence 4
Laser fluorescence measurement at the surface of the lesion
Time frame: 18-24 months
Caries lesion fluorescence 5
Laser fluorescence measurement at the surface of the lesion
Time frame: 24-30 months
No study locations are listed for this record.
Ran from Jan 2017 to primary completion in Nov 2019, 34 months.
Of 21 interventional studies with no phase under Root Caries, half reached primary completion within 30 months of starting (the median), counting those still running; a quarter within 23 and three quarters within 55. This study's 34 months is above that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Roseman University of Health Sciences