An observational study in Allergic Contact Dermatitis, sponsored by Universidad Autonoma de San Luis Potosí. Completed at 1 site in Mexico. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2020-04-29.
Sponsored by Universidad Autonoma de San Luis Potosí · Observational
Background. Allergic Contact Dermatitis (ACD) is an inflammatory skin disease mediated by direct contact with allergens as nickel, the most common allergen, that may be related with epigenetic changes.
Objective. Evaluate the miR-126 expression and its target VCAM-1, in the skin of patients with ACD to nickel.
Methods. Fifteen patients with positive patch test to nickel were included, and the expression of miR-126 and VCAM-1 was evaluated by RT-qPCR.
Patients that went to the dermatology and outpatient department of the Central Hospital "Dr. Ignacio Morones Prieto ", with a suspected diagnosis of nickel allergic contact dermatitis, were invited to participate in this study. Later, the objective and methodology of the study were explained to them, as well as the advantages of participating and the possible undesirable effects. All patients signed the informed consent previous perfom the medical history. After, the epicutaneous patch test was performed, and patients were divided according to the result them. Finally, under local anesthesia, two 3-mm punch biopsies, from lesional (positive parch test site) and adjacent non lesional skin, 10 cm apart, were performed. Tissues for reverse transcriptase real-time polymerase chain reaction (RT-qPCR) analyses were stored frozen in sterile tubes at 80ºC until processing
1,435 studies on the registry are indexed under Dermatitis; 131 are open to participants now.
This study's enrollment of 15 is below the median of 100 across 232 observational studies indexed under Dermatitis.
Browse Dermatitis studies →Universidad Autonoma de San Luis Potosí is the lead sponsor of 40 studies on the registry; 3 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Female and male patients with allergic contact dermatitis for more than one year
Exclusion Criteria:
Patients with positive epicutaneous patch test to nickel
Patients with negative epicutaneous patch test to nickel
Expression of miR-126
Relative expression of the miR-126 on skin biopsies from ACD patients
Time frame: 9 months
Plan to share: Undecided
This study is completed, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Universidad Autonoma de San Luis Potosí