An interventional study of Grape seed extract mouthwash and Sodium fluoride mouthwash in Dental Caries, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 13 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-17.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
This clinical trial will be conducted to compare the efficacy of grape seed extract oil versus sodium fluoride mouth wash in the management of remineralization in adult patients with white spot lesion over six months.
Natural products have long been used in traditional medicine and are promising sources for novel therapeutic agents, especially in treating oral diseases such as dental caries.
Previously, herbs are used in dentistry for prevention and curative purpose of dental caries. The main advantages of using herbal alternatives are easy availability, cost effectiveness, increased shelf life, low toxicity, and lack of microbial resistance.
Grape seed extract (GSE) has been found to be a promising natural remineralizing agent for treatment of the demineralized tooth.
Grape seed extract (GSE), a readily available over the counter supplement, has been noted for its potential dental restorative and caries preventative properties as a potent antioxidant. There are multiple bioactive properties in GSE, but in particular, its rich content of proanthocyanidins (PACs) plays a role in its theoretical benefit in caries prevention.
PACs have hydrophobic and hydrophilic properties, which enhance their ability to irreversibly bind to a variety of compounds, particularly minerals, proteins, and carbohydrates.
The remineralization effect of GSE appears to be featured. First, it participates in mineral deposition on the superficial layer of the lesion through forming insoluble complexes and combines with calcium to enhance remineralization. Second, GSE may interact with the organic portion of enamel through PA-collagen interaction, thereby stabilizing the exposed collagen matrix.
Proanthocyanidin (PA) has been proved to strengthen collagen-based tissues by increasing collagen cross-links. It is claimed that it can increase collagen synthesis and accelerates the conversion of soluble collagen into insoluble collagen. Proanthocyanidin has proved safe in different clinical applications and has been used as dietary supplements as well.
1,137 studies on the registry are indexed under Dental Caries; 201 are open to participants now.
This study's enrollment of 40 is below the median of 60 across 936 interventional studies indexed under Dental Caries.
Browse Dental Caries studies →Cairo University is the lead sponsor of 4,907 studies on the registry; 1,445 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
Grape seed extract mouth wash 15% concentration
Other: Grape seed extract mouthwash
Sodium fluoride mouthwash 1000 ppm
Other: Sodium fluoride mouthwash
Mouthwash 15% grape seed extract
Also known as: Grape seed extract
Sodium fluoride mouthwash
Remineralization of white spot lesions
changes in fluorescence of white spot lesions will be evaluated after reminerlization by using Diagnodent scoring (0-20)
Time frame: Evaluation of tooth surface changes at baseline and at 1, 3 and 6 months after starting treatment .
Satisfaction of the patient: questionnaire
Using binary questionnaire ( Yes/No)
Time frame: After 6 months
This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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