An observational study in Primary Immunodeficiency, sponsored by University Hospital, Montpellier. Status unknown at 1 site in France. Open to participants aged 1 Month to 16 Years. Per ClinicalTrials.gov, last updated 2021-10-12.
Sponsored by University Hospital, Montpellier · Observational
Currently about 90 cases of infection in children are reported every year in pediatric intensive care, a disease considered to be the main cause of hospitalization of children. 16% of invasive pneumococcal infections are linked to a genetic abnormality in immunity. Herpetic encephalitis has become a model of genetic infectious disease, with new mutations identified in the TLR3 pathway. Severe infections are no longer the result of chance and can be the way to reveal a primary immune deficiency. In this context, the investigators propose to evaluate the incidence of hereditary immune deficiency after a systematic immunological screening in children admitted for a severe infection in pediatric intensive care unit (ICU).
Severe infection requiring admission in intensive care unit (ICU) are not so rare. A retrospective pilot study conducted at Montpellier University Hospital Center (UHC) between 2013 and 2015 showed that 19.7% of the pediatric ICU admissions were related to a severe infection. An isolated severe infectious episode could be related to a hereditary immune deficiency (HID), even though there are no history of recurrent clinical signs and biological stigmata. For example, Gaschignard and colleagues considered that 16% of the invasive pneumococcal infections are related to a genetic defect of immunity (doi: 10.1093/cid/ciu274). Growing evidence has shown that severe infectious diseases occurring in childhood are attributed to inborn errors of immunity (doi: 10.1073/pnas.1521651112). While the nosology of severe infections has strong links to inherited immune deficiency that are rare diseases affecting less than 1 birth / 5000, there are no prospective studies that assessed the incidence of primary immune deficiencies in children who presented a severe infection.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's planned enrollment of 90 is below the median of 240 across 2,136 observational studies indexed under Infections.
Browse Infections studies →University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
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Pediatric population
Exclusion criteria:
Immunological abnormalities
Immunological abnormalities : based on the screening test
Time frame: 1 day
Diagnosis of primary immunodeficiency
Diagnosis of primary immunodeficiency
Time frame: 1 day
duration of hospitalization
Compare the duration of hospitalization enter the group treated by alone antibiotic and the group treated by antibiotic and surgical drainage.
Time frame: 1 day
Plan to share: Undecided — NC
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University Hospital, Montpellier