An observational study in Brown Fat and Muscle Metabolic and Differential Diagnosis, sponsored by Tang-Du Hospital. Status unknown at 1 site in China. Open to participants aged 15 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-06.
Sponsored by Tang-Du Hospital · Observational
False positives for Brown Fat \& Muscle（F\&M） always affect the evaluation of metabolic disease treatment. Recently, using PET/CT，international journals such as Journal of Nuclear Medicine reported that the amount of active brown fat was correlated with renal creatinine clearance and subject to regulation by atrial natriuretic peptide in addition to association of season and temperature. At present，studies based on PET/CT have shown that elimination of the above factors, brown fat(even muscle) will still appear false positive metabolism in tumor patients. In view of the basis of Positron emission computed tomography/Magnetic resonance (PET/MRI) brain function research，our team speculate that it may be related to psychological or cortex metabolism. And there is a lack of studies on the correlation between the psychosocial，cortex structure and metabolism. Therefore, it suggests that，combination of structure and metabolism，PET/MRI will play a role in studying the effects of psychological on F\&M false-positive metabolism in malignant patients. In this project, the investigators intend to observe the changes of F\&M metabolism with psychological and cortex metabolism after comprehensive treatment in malignant patient by combining PET/MRI. The relationship between F\&M metabolism and psychological will be deeply analyzed to provide scientific basis for the development of the differential diagnosis and assessment.
Tang-Du Hospital is the lead sponsor of 164 studies on the registry; 77 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients of the Tangdu hospital
Inclusion Criteria for Healthy Control Participants:
Exclusion Criteria:
The baseline PET/MR scan was performed before comprehensive treatment, and the contrast scan was performed after treatment and the sequence and protocol was consistent. Get psychological assessment before and after treatment and the time interval shall not exceed half a year
Other: Comprehensive treatment of tumor
The baseline PET/MR scan was performed before comprehensive treatment, and the contrast scan was performed after treatment and the sequence and protocol was consistent. Get psychological assessment before and after treatment and the time interval shall not exceed half a year
Other: Comprehensive treatment of tumor
Corresponding to the observation group, the time, sequence and protocol were consistent
According to the pathologic types and TNM stage of tumor，specialists chose one or more of the interventions in surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy.
Change metabolism of glucose of M&F
Glucose metabolic scores will be assessed with visual scale
Time frame: Baseline, 1 day ( Contrast scanning)
Change of the glucose metabolism area of M&F
Five different anatomical locations (subphrenic, paravertebral, mediastinal, cervical, supraclavicular) will be assessed with visual.
Time frame: Baseline, 1 day ( Contrast scanning)
Change of activated M&F volume
Activated M\&F volume before and after comprehensive treatment were evaluated by post-processing software
Time frame: Baseline, 1 day ( Contrast scanning)
Change of M&F SUVmax and SUVmean
SUVmax and SUVmean scores will be measured by post-processing software.
Time frame: Baseline, 1 day ( Contrast scanning)
Change of anxiety symptoms
Anxiety symptoms scores will be assessed with Hamilton Anxiety Scale.
Time frame: Baseline, 1 day ( Contrast scanning)
Change of sleep
Sleep scores will be assessed with Pittsburgh sleep quality index one month before scanning
Time frame: Baseline, 1 day ( Contrast scanning)
Change of metabolism of glucose in the M&F
Accumulation of 18F-FDG will be analyzed by treatment-related, psychology-related and intervention-related Positron emission tomography/ Magnetic resonance
Time frame: Baseline, 1 day ( Contrast scanning)
Plan to share: No
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This study is status unknown, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Tang-Du Hospital