An observational study in Hypogonadism, Male, sponsored by The Royal Wolverhampton Hospitals NHS Trust. Completed at 1 site in United Kingdom. Open to male participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-06.
Sponsored by The Royal Wolverhampton Hospitals NHS Trust · Observational
The purpose is to evaluate Sal-T against standard biomarkers of male gonadal status based on serum T, calculated free T and BAT. The optimal salivary sampling in terms of fasting and time of day will also be defined.
The ultimate aim is to add Sal-T into the Trust's repertoire of tests in investigating suspected hypogonadism in men.
To investigate whether salivary (free) testosterone is subject to similar prandial variations reported for serum total testosterone.
Study 1:
Assessment of diurnal variation in salivary testosterone adjusted for prandial state in 20 healthy men.
Study 2:
Measurement of salivary and serum testosterone and related biomarkers before and after a standard 75g oral glucose load in 40 men.
75 studies on the registry are indexed under Eunuchism; 21 are open to participants now.
This study's enrollment of 40 is below the median of 100 across 17 observational studies indexed under Eunuchism.
Browse Eunuchism studies →The Royal Wolverhampton Hospitals NHS Trust is the lead sponsor of 51 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Healthy volunteers and patients attending hospital for their OGTT as part of their stnadard care.
For 1st part of study -volunteers:
Inclusion Criteria:
Exclusion Criteria:
Obesity defined as a (BMI) of greater than 29.9 kg/m2As
2nd part of study for glucose load - oral glucose tolerance test (OGTT):
Inclusion criteria:
Exclusion criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Assessment of diurnal variation in salivary testosterone adjusted for prandial state
Other: Testosterone Measurements in healthy volunteers after fasting
Measurement of salivary and serum testosterone and related biomarkers before and after a standard 75g oral glucose load
Other: Testosterone Measurements after glucose loading
salivary testosterone measurements taken in morning and evening and a single blood test for testosterone taken
salivary tstosterone and blood testosterone measurements
Changes in salivary testosterone during the day independent of prandial state
testosterone levels
Time frame: 24 hours
Changes in salivary testosterone following an oral glucose load
testosterone levels
Time frame: 2 hours
Plan to share: No
This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.
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The Royal Wolverhampton Hospitals NHS Trust