CClinicalTrials.gg
CompletedNCT04323683Updated Mar 26, 2020

The Effect of Progesterone on Human Endometrium

An observational study in Fertility, sponsored by University of Nottingham. Completed at 1 site in United Kingdom. Open to female participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-03-26.

Sponsored by University of Nottingham · Observational

Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
12
Ages
18 Years to 35 Years
Sex
Female
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Study summary

This study evaluates the relationship between progesterone levels and endometrial gene expression

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Conditions studied

  • Fertility
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In context

Lead sponsor

University of Nottingham is the lead sponsor of 455 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 35 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Fertile women

Inclusion criteria

  • Ages 18-35, regular menstrual cycles, the cycle length between 25 and 35 days, body mass index (BMI) between 18 - 25

Exclusion criteria

Exclusion Criteria:

  • History of infertility, history of pelvic pain or/and endometriosis, history of pelvic mass, history of hormonal therapy in the last 3 months
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Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
12 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Low progesterone

    Women with progesterone level below 15 ng/ml

    Genetic: Microarray

  • Normal progesterone

    Women with progesterone level above 15 ng/ml

    Genetic: Microarray

Interventions

  • GeneticMicroarray

    High throughput technique for determining global gene expression of the condition of interest

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What researchers measure

Primary outcomes

  1. Differentially expressed genes between women with low and normal progesterone

    Fold-change and p-value were used to determine differentially expressed genes using Partek software

    Time frame: 2 months

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Study locations

1 site
  • Queen's medical center
    Nottingham, NG7 2UH, United Kingdom
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 26, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT04323683
Lead sponsor
University of Nottingham
Responsible party
Walid Maalouf (Course Director MMedSci Assisted Reproduction Technology, Faculty of Medicine & Health Sciences, University of Nottingham) — Principal investigator
First posted
Mar 26, 2020
Start date
Feb 1, 2019
Primary completion
Jul 31, 2019
Completion
Jul 31, 2019
Last update
Mar 26, 2020

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.

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