An observational study in HIV Infections, Non Communicable Diseases and Aging, sponsored by Makerere University. Status unknown. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2020-03-18.
Sponsored by Makerere University · Observational
The overall goal of the proposal is to improve capacity for detection and management of non-communicable diseases and geriatric syndromes in the aging HIV population in sub-Saharan Africa
The establishment and scale up of solid and sustainable HIV programs in sub-Saharan Africa (SSA) has led to a reduction in mortality and morbidity from HIV related opportunistic infections and some HIV related cancers. This improved survival has resulted in two phenomena: the first is the surfacing of non-communicable diseases (NCDs) in the HIV population, especially in those on long-term ART, and the second is increased longevity leading to increasing numbers of elderly HIV infected individuals
128 studies on the registry are indexed under Noncommunicable Diseases; 44 are open to participants now.
This study's planned enrollment of 500 is below the median of 1,748 across 43 observational studies indexed under Noncommunicable Diseases.
Browse Noncommunicable Diseases studies →Makerere University is the lead sponsor of 143 studies on the registry; 16 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients 60 years and above at IDI are referred to the elderly specialist clinic, which is run once a week by a physician, therefore study participants will be identified from this clinic. Enrolment into the Geriatric cohort will be offered to all patients 60 years and above attending attending their monthly routine clinic visit at the elderly specialist clinic will be approached by the study staff, will be given detailed information and be asked if they are willing to participate.
Age 60 years and above
Exclusion Criteria:
The cohort will recruit HIV infected participants who are on antiretroviral treatment
Also known as: Assessment of non communicable diseases and geriatric syndromes
Change in proportion of participants with any non communicable disease
Proportion with any non communicable disease (including hypertension, cardio vascular disease, respiratory disease, renal disease, non HIV related cancers, frailty)
Time frame: Enrollment, year 1, year 2
Change in Quality of life
Quality of life measured using the WHO Quality of life for elderly (WHOQOL-OLD)
Time frame: Enrollment, year 1, year 2
Change in proportion of patients with polypharmacy monitoring
Polypharmacy defined as 5 or more drugs beyond antiretroviral drugs, used in the same individuals for more than 4 weeks. Information of polypharmacy will be collected by the clinic files and self reported by the participants
Time frame: Enrollment, year 1, year 2
Change in Nutritional status assessed by Mini Nutritional Assessments (MNA)
Nutrition screening and assessment to identify geriatric patients age who are malnourished or at risk of malnutrition.
Time frame: Enrollment, year 1, year 2
Change in proportion of patients with history of falls
Occurrence of falls measured with the History of Falls questionnaire
Time frame: Enrollment, year 1, year 2
Change in proportion of patients with urinary incontinence measured by ICIQ-UI Short
Presence of urinary incontinence measured with the Internal Consultation on Incontinence Questionnaire
Time frame: Enrollment, year 1, year 2
Change in proportion of patients with depression
Depression measurement using the People Health Questionnaire-9 (scale 0-30, higher: worse)
Time frame: Enrollment, year 1, year 2
Change in proportion of patients with disability
Assessment of the Instrumental Activities of Daily Living (score 0-8, higher: better)
Time frame: Enrollment, year 1, year 2
Change in proportion of patients with cognitive deficit
Screening using Montreal Cognitive Assessment (score 0-30; higher: better)
Time frame: Enrollment, year 1, year 2
No study locations are listed for this record.
Plan to share: Yes — At the end of the project the dataset generated from the study will be made available as per the EDCTP Horizon 2020 guidelines. These data will be de-identified prior to sharing widely. The data will be shared in form an excel CSV spreadsheet that will be shared by the PI once the necessary approvals are met. We currently do not have a repository for the data, however at the time of publishing in Open Access Journals, the data will be made available
Supporting information: Study protocol, Sap, Csr, Analytic code
No publications or documents are linked to this record.
This study is status unknown, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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