An interventional study of membrane peeling in Epiretinal Membrane, sponsored by Vienna Institute for Research in Ocular Surgery. Active, not recruiting at 1 site in Austria. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-06-04.
Sponsored by Vienna Institute for Research in Ocular Surgery · Not applicable, Interventional, and Basic science
ILM and ERM are routinely excised during surgery, as part of the surgical technique, and cultivation of hyalocytes will be performed ex vivo after surgery.
Hyalocytes, typically located 20 to 50μm anterior the internal limiting membrane (ILM), have the potential to contribute to development of epiretinal membranes (ERM) in presence of vitreoschisis. For macular holes, hyalocytes located on the ILM are hypothesized to contribute to the closure of the macular hole after application of the inverted ILM flap technique.
ILM is routinely excised during surgical repair of macular holes. During peeling of ERM it is excised in case of persisting wrinkling of the retinal surface or partial en bloc excision with the ERM. Furthermore, excision of ILM during ERM peeling is associated with significantly lower recurrence rates of ERM and better Long term visual acuity, according to the results reported by Chang et al. Removal of ERM and ILM is part of the surgical routine during surgical repair of macular holes and peeling of epiretinal membranes. Therefore, cultivation of excised ERM and ILM samples does not increase risks for patients in any way. During study it is planned to cultivate hyalocytes for investigation of their role in macular hole closure.
120 studies on the registry are indexed under Epiretinal Membrane; 14 are open to participants now.
This study's planned enrollment of 30 is below the median of 50 across 73 interventional studies indexed under Epiretinal Membrane.
Browse Epiretinal Membrane studies →Vienna Institute for Research in Ocular Surgery is the lead sponsor of 64 studies on the registry; 8 are open to participants now.
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Exclusion Criteria:
Hyalocytes from ERM and ILM are cultured in alphaMEM to examine their proliferation habits
Procedure: membrane peeling
ERM and ILM are peeled routinely during surgery
Proliferation of Hyalocytes
hyalocytes from ERM and ILM will be cultured and counted
Time frame: 9 days
This study is active, not recruiting, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.
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Vienna Institute for Research in Ocular Surgery