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CompletedNCT04301752Updated Mar 18, 2020

Cognitive Impairment and Neuropsychiatric Manifestations of Neurobrucellosis

An observational study in Brucellosis, sponsored by Mansoura University Hospital. Completed at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-03-18.

Sponsored by Mansoura University Hospital · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
82
Ages
18 Years and older
Sex
All
01

Study summary

Brucellosis is a common zoonotic infection in many parts of the world including the Mediterranean and Middle Eastern countries.

Neurobrucellosis may develop at any stage of disease and may have widely variable manifestations, including encephalitis, meningoencephalitis, radiculitis, myelitis, peripheral and cranial neuropathies, subarachnoid hemorrhage, and psychiatric manifestations.

Read the detailed description

Brucellosis is a common zoonotic infection in many parts of the world including the Mediterranean and Middle Eastern countries.

Neurobrucellosis may develop at any stage of disease and may have widely variable manifestations, including encephalitis, meningoencephalitis, radiculitis, myelitis, peripheral and cranial neuropathies, subarachnoid hemorrhage, and psychiatric manifestations.

The aimed is to shed light to the obscure areas of diagnosis in neurobrucellosis and have detailed general and neurologic features

02

Conditions studied

  • Brucellosis

Keywords

  • Brucellosis, neuropsychiatric manifestations, cognition
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

82 consecutive patients with brucellosis (18 patients with neuropsychiatric manifestations and 64 patients without neuropsychiatric manifestations) were recruited.

Inclusion criteria

  • Patients >18 years of age with laboratory-confirmed brucellosis

Exclusion criteria

Exclusion Criteria:

  • Previous neuropsychiatric disease
04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
82 participants (actual)
Patient registry
No

Groups and cohorts

  • Neurobrucellosis

    Brucellosis associated with neuropsychiatric manifestations

    Diagnostic Test: MoCA

  • Non-neurobrucellosis

    Brucellosis not associated with neuropsychiatric manifestations

    Diagnostic Test: MoCA

Interventions

  • Diagnostic testMoCA

    Cognitive function was assessed by using MoCA score. Cognitive impairment was considered present when MoCA scores were \<26. Maximum score is 30.

05

What researchers measure

Primary outcomes

  1. MoCA s

    Cognitive function was assessed by using MoCA score. Cognitive impairment was considered present when MoCA scores were \<26 .

    Time frame: 24 hours

06

Study locations

1 site
  • Mansoura University Hospital
    Mansoura, Egypt
07

References and documents

Publications

  • Young EJ. Brucella species. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases. 7th ed. Philadelphia: Churchill Livingstone, 2010:2921-5.
  • Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005 Jun 2;352(22):2325-36. doi: 10.1056/NEJMra050570. No abstract available. PubMed 15930423 ↗
  • Finn TB. Brucellosis. In: Cohen J, Powderly WG, eds. Infectious diseases. 2nd ed. New York: Elsevier, 2004:1665-9.
  • Eren S, Bayam G, Ergonul O, Celikbas A, Pazvantoglu O, Baykam N, Dokuzoguz B, Dilbaz N. Cognitive and emotional changes in neurobrucellosis. J Infect. 2006 Sep;53(3):184-9. doi: 10.1016/j.jinf.2005.10.029. Epub 2006 May 2. PubMed 16647757 ↗

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT04301752
Lead sponsor
Mansoura University Hospital
Responsible party
Ahmed Esmael (Assistant Prof of Neurology, Mansoura University Hospital) — Principal investigator
First posted
Mar 10, 2020
Start date
Feb 1, 2019
Primary completion
Jan 1, 2020
Completion
Mar 1, 2020
Last update
Mar 18, 2020

Study contacts

Esmael M Ahmed, MD
principal investigator · Assistant Prof of Neurology

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.

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