An observational study in Urothelial Carcinoma, sponsored by Assiut University. Status unknown. Per ClinicalTrials.gov, last updated 2020-03-05.
Sponsored by Assiut University · Observational
In this study, the investigators aim at:
Bladder cancer is the ninth most common cancer worldwide which seriously affects human health. In Egypt, it is the third common malignant tumor.
Urothelial carcinoma (UC) is considered the most common histologic type of bladder cancer.
It is well recognized that the biological behavior of several cancers is closely related to their blood supply. Tumor progression and metastasis have been long associated with tumor angiogenesis. However, several studies demonstrated that vascular targeting drugs which induce endothelial cell apoptosis have a little effect. So, it has been suggested that novel tumor microcirculation patterns may exist in these neoplasms.
Vasculogenic mimicry (VM), is a novel tumor microcirculation system. Maniotis et al initially discovered VM in melanoma and defined these channels to be composed of tumor basement membrane lined externally by tumor cells, lacking blood vessel endothelium and containing plasma and red blood cells. So VM can be distinguished using immunohistochemical (IHC) staining and histochemical double staining. VM is CD31- or CD34-negative (endothelial markers) and periodic acid-Schiff (PAS) positive.
Vasculogenic mimicry was detected in several malignant tumors. Several studies reported that VM can promote tumor progression and metastasis and it is positively associated with pathological grade, stage, recurrence and drug resistance. Previous studies which evaluate, the role of VM in urothelial carcinoma yield controversial results. So, the value of VM in urothelial carcinomas and its relation to the clinicopathologic parameters remains to be elucidated.
6,741 studies on the registry are indexed under Carcinoma; 1,161 are open to participants now.
This study's planned enrollment of 70 is below the median of 149 across 1,175 observational studies indexed under Carcinoma.
Browse Carcinoma studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
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The study will be conducted using formalin fixed paraffin embedded blocks of sixty cases of urothelial carcinomas . These blocks will be obtained from laboratory archives of the Pathology Department, Assiut University Hospital, Faculty of Medicine. Clinical data for this study will be obtained from laboratory archives of the pathology department, Assiut University Hospital, Assiut University.
Exclusion Criteria:
presence of recurrence of urothelial carcinoma
Other: formalin fixed paraffin embedded blocks
absence of recurrence of urothelial carcinoma
Other: formalin fixed paraffin embedded blocks
The study will be conducted using formalin fixed paraffin embedded blocks of seventy cases of urothelial carcinomas .CD31-PAS dual-staining will be performed to confirm the presence of VM.
Evaluate the presence of vasculogenic mimicry in urothelial carcinomas by CD31-PAS double staining
Time frame: baseline
Correlate the presence of vasculogenic mimicry with the clinicopathologic features in urothelial carcinoma.
Time frame: baseline
No study locations are listed for this record.
This study is status unknown, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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Assiut University