An observational study in Diabetes Mellitus, Type 2 and Healthy, sponsored by University of Colorado, Denver. Completed at 1 site in United States. Open to female participants aged 60 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-30.
Sponsored by University of Colorado, Denver · Observational
Sedentary behavior has been linked to cardiovascular morbidity and mortality, and is particularly common in older adults with type 2 diabetes. The purpose of this observational, mixed-methods study is to better understand the relationship between prolonged sedentary behavior and cardiovascular and metabolic health in older women.
The investigators will recruit 20 women age 60-75 years, n=10 with uncomplicated type 2 diabetes (T2D) and n=10 healthy controls. Participants will wear two accelerometers and a continuous glucose monitor (CGM) for two different periods of 7 days for objective assessment of physical activity, sedentary behavior, and blood glucose, respectively, and complete a graded exercise test (cardiorespiratory fitness), assessment of insulin sensitivity (hyperinsulinemic-euglycemic clamp) and single leg exercise using near-infrared spectroscopy (microvascular function). Participants will also complete a semi-structured qualitative interview to understand knowledge and attitudes toward sedentary behavior and questionnaires to assess the relationship between modifiable psychological and behavioral factors and sedentary behavior.
The aims of the study are to:
10,923 studies on the registry are indexed under Diabetes Mellitus; 1,318 are open to participants now.
This study's enrollment of 28 is below the median of 233 across 2,218 observational studies indexed under Diabetes Mellitus.
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Healthy women and women with T2D age 60-75 years.
Exclusion Criteria:
women age 60-75 years with uncomplicated type 2 diabetes mellitus
healthy women age 60-75 years
time sedentary measured via triaxial accelerometer
Time frame: 7 days
average sedentary bout length measured via triaxial accelerometer
Time frame: 7 days
cardiorespiratory fitness
peak volume of oxygen consumption (VO2 peak) in ml/kg/min measured via graded exercise test
Time frame: 8-12 minutes
insulin sensitivity
glucose infusion rate in mg/kg/min as measured via hyperinsulinemic-euglycemic clamp
Time frame: 3 hours
change in skeletal muscle deoxygenated hemoglobin concentration during single leg calf exercise measured via near-infrared spectroscopy
Time frame: 30 minutes
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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University of Colorado, Denver