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Status unknownNCT04244409INSITUUpdated Jan 28, 2020

INvestigational Study Into Transplantation of the Uterus

An observational study in Mayer-Rokitansky-Kuster Syndrome, Asherson's Syndrome and Postpartum Hemorrhage, sponsored by Womb Transplant UK. Status unknown at 1 site in United Kingdom. Open to female participants aged 24 Years to 38 Years. Per ClinicalTrials.gov, last updated 2020-01-28.

Sponsored by Womb Transplant UK · Observational

The sponsor has not verified this record recently (last verified Jan 2020), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
10
Ages
24 Years to 38 Years
Sex
Female
01

Study summary

Observational study on cohort of 10 women undergoing uterine transplantation using deceased donors

02

Conditions studied

  • Mayer-Rokitansky-Kuster Syndrome
  • Asherson's Syndrome
  • Postpartum Hemorrhage
  • Cervical Cancer

Keywords

  • Gynaecology
  • Immunosuppression
  • In-vitro Fertilisation
  • Infertility
  • MRKH
  • Pregnancy
  • Transplantation
  • Uterus
03

In context

Postpartum Hemorrhage

445 studies on the registry are indexed under Postpartum Hemorrhage; 76 are open to participants now.

This study's planned enrollment of 10 is below the median of 152 across 91 observational studies indexed under Postpartum Hemorrhage.

Browse Postpartum Hemorrhage studies →

Lead sponsor

Womb Transplant UK is the lead sponsor of 2 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
24 Years to 38 Years
Sexes eligible
Female
Sampling method
Non-probability sample

Study population

Women with absolute uterine factor infertility

Inclusion criteria

  1. Female
  2. Age - 24-38 (or 40 if eggs frozen \<38)

  3. AUFI

    1. Normal length vagina
    2. No renal pathology
  4. BMI \<30kg/m2
  5. ASA grade I
  6. Meet psychological criteria
  7. Meet HFEA criteria for IVF
  8. Eligible for NHS treatment
  9. Speak fluent English

Exclusion criteria

Exclusion Criteria:

  1. Unsuccessful oocyte retrieval (\<10 good quality embryos)
  2. Previous multiple/significant surgeries
  3. Severe endometriosis
  4. Cancer patients \<5 years in remission
  5. Previous living childbirth, adopted child or child born through surrogacy
  6. HIV or Hepatitis B / C positive
  7. Skin or intestinal neovagina
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
10 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Live birth rate

    Time frame: 5 years

Secondary outcomes

  1. Pregnancy rate

    Time frame: 5 years

  2. Transplant success rate

    Time frame: 3 years

07

Study locations

1 of 1 sites recruiting
  • Hammersmith Hospital, Imperial College NHS Trust
    London, W12 0HS, United Kingdom
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 28, 2020, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04244409
Lead sponsor
Womb Transplant UK
Collaborators
Oxford University Hospitals NHS Trust, Imperial College Healthcare NHS Trust
Responsible party
Ben Jones (Principal Investigator, Imperial College Healthcare NHS Trust) — Principal investigator
First posted
Jan 28, 2020
Start date
Feb 18, 2019
Primary completion
Feb 18, 2022 (estimated)
Completion
Feb 18, 2024 (estimated)
Last update
Jan 28, 2020

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.

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Discussion

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