A Phase 4 interventional study of Nefopam 20 MG/ML and Placebo in Pain, Postoperative, sponsored by Mahidol University. Completed at 1 site in Thailand. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-11-20.
Sponsored by Mahidol University · Phase 4, Interventional, and Treatment
Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's enrollment of 72 is close to the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Mahidol University is the lead sponsor of 730 studies on the registry; 118 are open to participants now.
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Exclusion Criteria:
Drug: Nefopam 20 MG/ML
Drug: Placebo
Nefopam group nefopam 20 mg during surgery and follow by 80 mg in 24 hours postoperative
Placebo
morphine consumption in first 24 hours post-operative
morphine consumption record from patient-controlled analgesia machine in 24 hours post-operative
Time frame: 24 hours
numeric pain score
numeric pain score in 1, 2, 12, 24 hours after surgery
Time frame: 24 hours
side effect of nefopam
side effect of nefopam: tachycardia, sweating, nausea, vomiting, sedation
Time frame: 24 hours
Plan to share: No
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This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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Mahidol University