An interventional study of inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day in Tonsillitis Streptococcal, sponsored by Combined Military Hospital, Pakistan. Completed at 1 site in Pakistan. Open to participants aged 5 Years to 15 Years. Per ClinicalTrials.gov, last updated 2020-01-03.
Sponsored by Combined Military Hospital, Pakistan · Not applicable, Interventional, and Treatment
To compare intravenous Co-amoxiclav versus Benzyl penicillin in children with severe streptococcal tonsillitis in terms of efficacy, safety and cost effectiveness.
Efficacy was measured through improvement (decrease in fever, settling lymphadenopathy and disappearance of tonsillar exudate) in Centor Criteria score on daily basis. Improvement i.e reduction in Centor Criteria score was recorded for all children till full recovery.
Safety was measured by frequency of hypersensitivity reactions or severe side effects of antibiotics necessitating stoppage of the drug. All the children in both Groups were given test dose of the antibiotic before giving full dose of antibiotic prescribed.
Cost effectiveness was compared in terms of total cost of injections (Co-amoxiclav versus Benzyl penicillin) which were administered to children in both groups.
104 studies on the registry are indexed under Tonsillitis; 12 are open to participants now.
This study's enrollment of 310 is above the median of 100 across 89 interventional studies indexed under Tonsillitis.
Browse Tonsillitis studies →Combined Military Hospital, Pakistan is the lead sponsor of 14 studies on the registry; 3 are open to participants now.
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Group A children were advised Inj Co-amoxiclav 50 units/kg/day in 3 divided doses daily
Drug: inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Group B patients were advised inj Benzyl Penicillin 25000 units/kg/day in 3 divided doses
Drug: inj co-amoxiclav 50 units/kg/day vs inj Benzyl Penicillin 25000 units/kg/day
Patients of both groups were examined and compared in terms of efficacy of treatment, safety and cost effectiveness
Also known as: Group A and B
treatment efficacy
full recovery (Centor score became zero/nil)
Time frame: 10 days
Plan to share: No — It will not be shared
No publications or documents are linked to this record.
Ran from Jan 2018 to primary completion in Nov 2019, 22 months.
Of 29 non-industry interventional studies with no phase under Tonsillitis, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 49. This study's 22 months is close to that.
Counting every sponsor, half of 29 studies reached it within 20 months; a quarter within 10 and three quarters within 49.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Dec 2019. You cannot join it, but the record below documents what was studied.
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Combined Military Hospital, Pakistan