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Status unknownNCT04204148Updated Dec 18, 2019

To Explore the Related Factors of Cough After Thoracoscopic Pneumonectomy

An observational study in Cough, sponsored by The First Affiliated Hospital of Soochow University. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-12-18.

Sponsored by The First Affiliated Hospital of Soochow University · Observational

The sponsor has not verified this record recently (last verified Dec 2019), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
120
Ages
18 Years and older
Sex
All
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Study summary

To explore the related factors of cough after Uniport video-assisted thoracoscopic surgery pneumonectomy, and to provide theoretical basis and social accumulation of new knowledge for the diagnosis and treatment of cough after pneumonectomy in the future.

Read the detailed description

Intractable cough after thoracoscopic pneumonectomy is one of the common complications after pneumonectomy. The incidence of cough can reach 25% ≤ 50%. Cough after operation can aggravate the pain of incision, prolong the hospitalization time, increase the cost of hospitalization, affect the conversation and even sleep of the patients, increase the psychological burden of the patients, and reduce the quality of life of the patients accordingly. Therefore, through this study, the investigators hope to understand the related factors of cough after thoracoscopic pneumonectomy and whether there are predictable risk factors, so as to provide theoretical basis for reducing the occurrence of cough after pneumonectomy.

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Conditions studied

  • Cough

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Keywords

  • postoperative cough
  • Multivariate analysis
  • non-small cell lung cancer (NSCLC)
  • Uniport Video-assisted Thoracoscopic Surgery
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In context

Cough

346 studies on the registry are indexed under Cough; 71 are open to participants now.

This study's planned enrollment of 120 is above the median of 94 across 75 observational studies indexed under Cough.

Browse Cough studies →

Lead sponsor

The First Affiliated Hospital of Soochow University is the lead sponsor of 252 studies on the registry; 148 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Age ≥ 18 years old, male and female

Inclusion criteria

  • Age ≥ 18 years old, male and female
  • Uniport video-assisted thoracoscopic surgery
  • No cough symptoms within two weeks before operation
  • Informed consent form was signed before operation

Exclusion criteria

Exclusion Criteria:

  • Diabetes , heart, brain, liver and kidney diseases
  • Chest radiographs / CT in recent months indicate pneumonia
  • Pulmonary function cannot tolerate lobectomy / segmental / cuneiform resection
  • Distant metastasis patients
  • Before operation, there were internal causes of cough (including respiratory tract infectious diseases, pharyngitis, allergic rhinitis, posterior nasal drip syndrome, etc.)
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
120 participants (estimated)
Target follow-up
3 Months
Patient registry
Yes

Groups and cohorts

  • Clinical characteristics of the patients

    including sex,age,smoking history,tumor location and tumor diameter

  • Logistic regression analysis of influencing factors of c

    The Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) was used to evaluate the degree of cough in patients. The LCQ-MC is divided into three dimensions: physical, psychological and social. There are a total of 19 questions, and each question has seven options (positive scoring, grades 1-7; the higher the score is, the lighter the cough).

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What researchers measure

Primary outcomes

  1. The mean Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC) score before and after surgery

    The Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC), which assesses the cough-related quality of life, consists of 19 items divided into three domains: the physical (8 items), psychological (7 items) and social (4 items) domains. A 7-point Likert scale was used to score individual domains. The total scores ranged from 3 to 21, with a higher score indicative of a better health status

    Time frame: The day before surgery,two weeks after surgery,one month after surgery

Secondary outcomes

  1. Hospitalization days

    The numbers of days of patients stay in the hospital after surgery

    Time frame: From the first days after surgery to discharge,up to 4 weeks

  2. Drainage

    The total volume of fluid

    Time frame: Measure the volume every 24 hours,up to 4 weeks

  3. Anesthesia time

    Time from patient anesthesia to extubation

    Time frame: Record total anesthesia during surgery

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Study locations

1 of 1 sites recruiting
  • The First Affiliated Hospital of Soochow University
    Suzhou, Jiangsu 215000, China
    Recruiting
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References and documents

Publications

  • Dicpinigaitis PV, Rauf K. The influence of gender on cough reflex sensitivity. Chest. 1998 May;113(5):1319-21. doi: 10.1378/chest.113.5.1319. PubMed 9596313 ↗
  • Birring SS, Spinou A. How best to measure cough clinically. Curr Opin Pharmacol. 2015 Jun;22:37-40. doi: 10.1016/j.coph.2015.03.003. Epub 2015 Mar 25. PubMed 25819594 ↗
  • Harle ASM, Blackhall FH, Molassiotis A, Yorke J, Dockry R, Holt KJ, Yuill D, Baker K, Smith JA. Cough in Patients With Lung Cancer: A Longitudinal Observational Study of Characterization and Clinical Associations. Chest. 2019 Jan;155(1):103-113. doi: 10.1016/j.chest.2018.10.003. Epub 2018 Oct 13. PubMed 30321508 ↗
  • Brignall K, Jayaraman B, Birring SS. Quality of life and psychosocial aspects of cough. Lung. 2008;186 Suppl 1:S55-8. doi: 10.1007/s00408-007-9034-x. Epub 2007 Oct 16. PubMed 17939003 ↗
  • Xie MR, Zhu YF, Zhou MQ, Wu SB, Xu GW, Xu SB, Xu MQ. Analysis of factors related to chronic cough after lung cancer surgery. Thorac Cancer. 2019 Apr;10(4):898-903. doi: 10.1111/1759-7714.13021. Epub 2019 Mar 15. PubMed 30875149 ↗
  • Koskela HO, Latti AM, Pekkanen J. The impacts of cough: a cross-sectional study in a Finnish adult employee population. ERJ Open Res. 2018 Nov 12;4(4):00113-2018. doi: 10.1183/23120541.00113-2018. eCollection 2018 Oct. PubMed 30443552 ↗
  • Wang P, Zhu M, Zhang D, Guo XG, Zhao S, Zhang XL, Wang DL, Liu CT. The relationship between chronic obstructive pulmonary disease and non-small cell lung cancer in the elderly. Cancer Med. 2019 Aug;8(9):4124-4134. doi: 10.1002/cam4.2333. Epub 2019 Jun 11. PubMed 31184445 ↗
  • Pan LY, Peng LP, Xu C, Ding C, Chen J, Wang WY, Zhu XY, Zhao J, Li C. Predictive factors of cough after uniportal video-assisted thoracoscopic pulmonary resection. J Thorac Dis. 2020 Oct;12(10):5958-5969. doi: 10.21037/jtd-20-2652. PubMed 33209428 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 18, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04204148
Lead sponsor
The First Affiliated Hospital of Soochow University
Responsible party
Sponsor
First posted
Dec 18, 2019
Start date
Dec 1, 2019
Primary completion
Mar 2020 (estimated)
Completion
Apr 2020 (estimated)
Last update
Dec 18, 2019

Study contacts

Jun Zhao
Contact
zhaojia0327@126.com
13906130266
Chang Li
Contact
cli@suda.edu.cn
15295666957
Liping Peng
principal investigator · The First Affiliated Hospital of Soochow University
Liuying Pan
principal investigator · The First Affiliated Hospital of Soochow University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is status unknown, as verified in Dec 2019. You cannot join it, but the record below documents what was studied.

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