An interventional study of remote ischemic conditioning in 2,3-Bisphosphoglycerate, sponsored by Capital Medical University. Status unknown. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-12-01.
Sponsored by Capital Medical University · Not applicable, Interventional, and Basic science
Under hypoxia or high-altitude hypoxia ,it has been found that 2,3-bisphosphoglycerate(2,3-BPG) in erythrocyte increased and facilitated oxygen release to tissues.Remote Ischemic Conditioning(RIC) can also cause hypoxic conditions in local limbs.Thus,we hypothesize that whether RIC could also increase 2,3-BPG in erythrocyte.
RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently and has been proved to be effective in ischemic stroke and myocardial infarction(MI).The possible mechanisms of RIC protection is complicated.RIC leads to local ischemia and hypoxia and has been demonstrated to play a role in vital organs through hypoxia inducible factors(HIF) against stroke and MI.Besides HIF, hypoxia or high-altitude hypoxia could also change glycolytic process in erythrocyte through adenosine or sphingosine-1-phosphate(S1P).Accompanying with alternating glucolysis, 2,3-diphosphoglycerate(2,3-BPG) in erythrocyte increases and it also facilitating oxygen release to tissues.Thus,we hypothesize that whether RIC could also increase 2,3-BPG in erythrocyte.There are 8 arms in this trial: All arms are RIC treatment. The level of 2,3-BPG in erythrocyte will be assessed by ELISA before and after the treatment.
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RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral upper limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral upper limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral upper limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral upper limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral lower limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral lower limb and inflated to 60 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on unilateral lower limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral lower limb and inflated to 200 mmHg for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Device: remote ischemic conditioning
RIC is induced by short-term insulting blood-flow of nonvital distant organs intermittently.
Changes of 2,3-BPG levels in erythrocyte
Whole blood for testing effect of RIC on 2,3-BPG in Erythrocyte
Time frame: through study completion, an average of 24 hours
Changes of prothrombin time(PT)
Whole blood for testing effect of RIC on PT
Time frame: through study completion, an average of 24 hours
Changes of activated partial thromboplastin time(APPT)
Whole blood for testing effect of RIC on APPT
Time frame: through study completion, an average of 24 hours
Changes of activated partial thrombin time(TT)
Whole blood for testing effect of RIC on TT
Time frame: through study completion, an average of 24 hours
Changes of Fibrinogen(FIB)
Whole blood for testing effect of RIC on FIB
Time frame: through study completion, an average of 24 hours
Changes of D-dimer
Whole blood for testing effect of RIC on D-dimer
Time frame: through study completion, an average of 24 hours
Changes of hypoxia inducible factor-1(HIF-1)
Whole blood for testing effect of RIC on HIF-1
Time frame: through study completion, an average of 24 hours
Changes of lower limbs venous blood flow
Vascular ultrasound for detecting venous blood flow in lower limbs
Time frame: through study completion, an average of 24 hours
No study locations are listed for this record.
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Capital Medical University