An observational study in Allergic Disorder, sponsored by Brugmann University Hospital. Status unknown at 1 site in Belgium. Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2022-07-19.
Sponsored by Brugmann University Hospital · Observational
In 2001-2002, a longitudinal study on the risk of atopic sensitization in children was conducted by the Pneumo-Allergology and Pediatrics departments of the CHU Saint-Pierre Hospital and at the Neonatology Department of the Queen Fabiola Children's University Hospital (HUDERF). The aim of the study was to study bacteria and endotoxins in airborne dust in Brussels homes in order to evaluate their impact on the development of allergic diseases in newborns.
Between December 2000 and August 2002, 114 children (67 from HUDERF and 47 from CHU St-Pierre) were included in the study. These were eutrophic children without acquired pathology or known genetics.
Simultaneously a microbial habitat assessment was performed based on a detailed description and on endotoxin assays in the airborne and deposited dust (mainly mattress).These data can be used to define habitats with high or low contamination.Samples for microbial analyzes (Gram positive and negative and mold) were also carried out.
Preliminary results suggested:
In this current, new study, the investigators will recontact the children who were included in the 2003 study. The goal is to evaluate them clinically and allergically and associate the risk of sensitization / allergic diseases with the microbial exposure of the habitat, measured during the neonatal period.
Siblings and parents who were exposed during the same period will also be evaluated.
1,916 studies on the registry are indexed under Hypersensitivity; 265 are open to participants now.
This study's planned enrollment of 320 is above the median of 115 across 479 observational studies indexed under Hypersensitivity.
Browse Hypersensitivity studies →Brugmann University Hospital is the lead sponsor of 116 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Children who participated in the study conducted in 2001-2002, their parents and the siblings who were exposed to the same environment at this period.
Children who participated in the study conducted in 2001-2002, their parents and the siblings who were exposed to the same environment at this period.
Exclusion Criteria:
None
Children who participated in the study conducted in 2001-2002, their parents and the siblings who were exposed to the same environment at this period.
Diagnostic Test: Clinical evaluation
The assessment is based on a comprehensive questionnaire, a simple clinical examination, an spirometry test, allergic skin tests, measurement of the exhaled fraction of NO (FeNO) and blood serum analysis.
Prevalence of positivity of allergic skin tests
Prevalence of positivity of allergic skin tests
Time frame: 1 year
Prevalence of positivity of ImmunoCAP tests
Prevalence of positivity of ImmunoCAP tests
Time frame: 1 year
Prevalence of clinical manifestations of allergy
Prevalence of clinical manifestations of allergy (atopic eczema, food allergy, asthma and rhinitis).
Time frame: 1 year
Prevalence of confirmed asthma
Prevalence of confirmed asthma (clinical manifestations, spirometry and FeNO)
Time frame: 1 year
Spirometry results
Spirometry results
Time frame: 1 year
Exhaled fraction of NO (FeNO) results
Exhaled fraction of NO (FeNO) results
Time frame: 1 year
Eosinophilia count
Eosinophilia count
Time frame: 1 year
Socio-cultural status
Socio-cultural status
Time frame: 1 year
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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Brugmann University Hospital