An interventional study of Nanofractures and no treatment cartilaginous lesions in Cruciate Ligament Rupture and Cartilage Injury, sponsored by Istituto Ortopedico Rizzoli. Terminated at 1 site in Italy. Open to participants aged 18 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-05-22.
Sponsored by Istituto Ortopedico Rizzoli · Not applicable, Interventional, and Treatment
The aim of the study is the evaluation of both clinical and radiological results in patients undergone to cruciate ligament reconstruction with concomitant cartilaginous lesion treated with or without nanofractures.
The anterior cruciate ligament lesion is one of the most common disease conditions in the orthopedic clinical practice. The mechanism of injury is due to a direct or indirect knee trauma causing both ligamentous breaking and surface articular stress, with cartilaginous lesion often associated to the lesion of the anterior cruciate ligament.
The treatment of these lesions in combination with the treatment of the anterior cruciate ligament is controversial, more controversial is to understand the indication to treatment for these lesions.
In order to clarify this aspect and provide a more reliable therapeutic indication for the treatment of the cartilaginous lesion with concomitant anterior cruciate ligament lesion we want to compare the clinical outcomes of the non-treated cartilaginous lesions against the treated cartilaginous lesions wiht nonofractures.
Istituto Ortopedico Rizzoli is the lead sponsor of 298 studies on the registry; 102 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients undergoing to anterior cruciate ligament reconstruction with concomitant treatment of the cartilaginous lesions with nanofractures technique.
Procedure: Nanofractures
Patients undergoing to anterior cruciate ligament reconstruction. Cartilaginous lesions won't be treated
Procedure: no treatment cartilaginous lesions
anterior cruciate ligament reconstruction will be performed in combination with the nanofractures for the treatment of cartilaginous lesions
patient undergoing to the anterior cruciate ligament reconstruction without treatment of the cartilaginous lesions
IKDC-subjective score (International Knee Documentation Committee)
It is a specific subjective rating scale for te knee. Iti s one of the most reliable tools for assessing knee diseases. The survey examines three categories: symptoms, sport activity, knee function.
Time frame: 24 month
WORMS (Whole-Organ Magnetic Resonance Imaging Score)
Magnetic resonance imaging will be evaluated through WORMS. The score evaluated five aspects of the three knee compartments (cartilage, bone marrow abnormalities, bone cysts, bone attrition and osteophytes) as well as the soft tissue (menisci, ligaments and synovium)
Time frame: 24 month
IKDC-subjective score (International Knee Documentation Committee)
It is a specific subjective rating scale for te knee. Iti s one of the most reliable tools for assessing knee diseases. The survey examines three categories: symptoms, sport activity, knee function.
Time frame: 6, 12, 36 and 60 months
Tegner Activity Level Scale
Survey useful for assessing sport activity of the patient.
Time frame: 6, 12, 24, 36 and 60 months
KOOS (Knee injury and Osteoarthritis Outcome Score )
KOOS consists of 5 subscales; Pain, other Symptoms, Function in daily living (ADL), Function in sport and recreation (Sport/Rec) and knee related Quality of life (QOL). The previous week is the time period considered when answering the questions. Standardized answer options are given (5 Likert boxes) and each question is assigned a score from 0 to 4. A normalized score (100 indicating no symptoms and 0 indicating extreme symptoms) is calculated for each subscale
Time frame: 6, 12, 24, 36 and 60 months
EQ-5D (EuroQoL) Current Health Assessment
It is a reliable tools for assessing quality of life of the patient
Time frame: 6, 12, 24, 36 and 60 months
This study is terminated, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Istituto Ortopedico Rizzoli