An observational study in Oxidative Stress, Low Grade Squamous Intraepithelial Lesion and High-Grade Squamous Intraepithelial Lesions, sponsored by Muğla Sıtkı Koçman University. Completed at 1 site in Turkey. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-02-06.
Sponsored by Muğla Sıtkı Koçman University · Observational
The purpose of this study is to investigate Thiol-disulfide balance in patients with cervical preinvasive lesions
To date various oxidative stress paramaters were studied in patients with cervical preinvasive lesions, however dynamic thiol disulfide hemostasis has not been previously investigated. The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel \& Neselioglu(1).
References 1- Erel O, Neselioglu S. A novel and automated assay for thiol/ disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/ j.clinbiochem.2014.09.026.
49 studies on the registry are indexed under Squamous Intraepithelial Lesions of the Cervix; 13 are open to participants now.
This study's enrollment of 300 is close to the median of 300 across 15 observational studies indexed under Squamous Intraepithelial Lesions of the Cervix.
Browse Squamous Intraepithelial Lesions of the Cervix studies →Muğla Sıtkı Koçman University is the lead sponsor of 112 studies on the registry; 19 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The diagnosis of preinvasive cervical lesions was made histopathologically by cervical biopsy. An experienced pathologist performed histopathologic examinations
Exclusion Criteria:
low grade squamous intraepithelial lesion(LGSIL) n=100
Diagnostic Test: Disulphide(μmol/L) · Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)
high grade squamous intraepithelial lesion(HGSIL) n=100
Diagnostic Test: Disulphide(μmol/L) · Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)
Healthy volunteers n=100
Diagnostic Test: Disulphide(μmol/L) · Diagnostic Test: Total Oxidant Capacity(μmolH2O2Equiv/L)
Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry
Also known as: Native thiol (μmol/L), Total thiol (μmol/L), Nativethiol/totalthiol(%), Disulfide/nativethiol(%), Disulfide/totalthiol(%)
Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry
Also known as: Total Antioxidant Capacity(mmolTroloxEquiv/L), Oxidative stress Index (Arbitrary Unite)
serum native thiol level
serum native thiol level in μmol/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
serum disulphide level
serum disulphide level in μmol/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
serum total thiol level
serum total thiol level in μmol/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
the disulphide/native thiol ratio
the disulphide/native thiol ratio X (100 )
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
disulphide/total thiol ratio
disulphide/total thiol ratio X (100 )
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
native thiol/total thiol ratio
native thiol/total thiol ratio X (100 )
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
total antioxidant capacity (TAC)
TAC in mmol trolox equivalent/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
total oxidant capacity (TOC)
TOC in mmol H2O2 equivalent/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
Oxidative stress index (OSI)
OSI in mmol trolox/L.
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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Muğla Sıtkı Koçman University