An interventional study of Yo-Yo Intermittent Recovery Test Level 1 in MMP9, TIMP1 and MMP9 -1562 C/T, sponsored by Dokuz Eylul University. Completed at 1 site in Turkey. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-04-30.
Sponsored by Dokuz Eylul University · Not applicable, Interventional, and Basic science
Matrix metalloproteinases (MMPs) play a critical role in the remodeling and regeneration of skeletal muscle. Studies which investigate exercise and effects of MMPs and tissue inhibitors of matrix metalloproteinases (TIMPs) are contradictory. Also the role of MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms on exercise are unclear. In accordance with this conditions the hypothesis of the study are as follows:
Dokuz Eylul University is the lead sponsor of 252 studies on the registry; 32 are open to participants now.
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Group of athletes:
Group of sedentary people:
Exclusion Criteria(For two groups):
Age: 18-35 Gender: Male Basketball, volleyball, handball players who have been training regularly for at least last 3 months.
Other: Yo-Yo Intermittent Recovery Test Level 1
Age: 18-35 Gender: Male Individuals with similar physical characteristics to the group of athletes and who have not exercise regularly for at least last 3 months.
Other: Yo-Yo Intermittent Recovery Test Level 1
The test is a standard test battery with progressively increasing speeds. After every 40-m run (2x20 m), active rest is performed by walking or jogging at a distance of 10 m (2x5 m). for 10 seconds. Participants are trying to adjust their speed according to incoming audio signals.The test is terminated when the participants can not reach the signal twice. The test ends in 10-20 minutes depending on the level of participants. Reference Bangsbo, J., Iaia, F. M., \& Krustrup, P. (2008). The Yo-Yo intermittent recovery test. Sports medicine, 38(1), 37-51. Krustrup, P., Mohr, M., Amstrup, T., Rysgaard, T., Johansen, J., Steensberg, A., ... \& Bangsbo, J. (2003). The yo-yo intermittent recovery test: physiological response, reliability, and validity. Medicine \& Science in Sports \& Exercise, 35(4), 697-705.
Level of MMP9 and TIMP1
The effect of acute maximal exercise on serum MMP9 and TIMP1 levels in athletes and sedentary people.
Time frame: Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants)
MMP9 -1562 C/T, TIMP1 372 T/C polymorphisms
The role of MMP9 -1562 C/T and TIMP1 372 T/C polymorphisms on the effect of acute maximal exercise on serum MMP9 and TIMP1 in athletes and sedentary people.
Time frame: Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants)
Level of indicators of muscle damage and inflammation and oxidative stress
The relationship between primary outcome measures and indicators of muscle damage, inflammation and oxidative stress. Indicators to be determined: creatine kinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), Interleukin-6 (IL-6), C- reactive protein (CRP), total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO)
Time frame: Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants)
Level of blood lipids and lipoproteins, glucose, urea, creatinine, hemogram
The relationship between primary outcome measures and blood lipids and lipoproteins, glucose, urea, creatinine and hemogram
Time frame: Yo-Yo Intermittent Recovery Test level 1 (the test performed until the subject is exhausted, the test lasts 10-20 minutes according to endurance capacity of the participants)
Plan to share: Undecided
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Dokuz Eylul University