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CompletedNCT04137705MORISUpdated Dec 1, 2025

MultiOrgan Multi-Parametric MRI Study

An observational study in Type 2 Diabetes, sponsored by Perspectum. Completed at 3 sites in United Kingdom. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-01.

Sponsored by Perspectum · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
43
Ages
18 Years and older
Sex
All
01

Study summary

To determine the reproducibility of a single quantitative multiparametric MRI for the assessment of body composition and multiple organ structures.

02

Conditions studied

  • Type 2 Diabetes
03

In context

Diabetes Mellitus, Type 2

9,359 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,318 are open to participants now.

This study's enrollment of 43 is below the median of 300 across 1,588 observational studies indexed under Diabetes Mellitus, Type 2.

Browse Diabetes Mellitus, Type 2 studies →

Lead sponsor

Perspectum is the lead sponsor of 27 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Adult volunteers, including healthy volunteers and individuals with Type 2 Diabetes (T2D).

Inclusion criteria

  • Any person over 18 years of age.
  • Participant is willing and able to give informed consent for participation in the investigation.
  • EITHER: Participant has Type 2 Diabetes OR: Person is a healthy volunteer

Exclusion criteria

Exclusion Criteria:

  • The participant may not enter the investigation if they have any contraindication to magnetic resonance imaging (incl. pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia).
  • Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the investigation, or may influence the result of the investigation, or the participant's ability to participate in the investigation
05

Study design

Observational model
Other
Time perspective
Prospective
Enrollment
43 participants (actual)
Patient registry
No

Interventions

  • OtherMultiparametric MRI

    A standardised MRI protocol that provides a number of quantitative metrics on liver and other organs relevant to type 2 Diabetes - pancreas, kidneys, spleen, heart, lungs and aorta

06

What researchers measure

Primary outcomes

  1. Assessment of repeatability (precision under the same conditions in the same subjects: 2 separate MRI acquisitions on the same scanner) of body composition and multiple organ metrics.

    To determine the repeatability of multiparametric MRI in the assessment of body composition and multiple organ structures obtained within a single MR scanning session (liver, pancreas, aorta, heart, kidney, lungs and spleen)

    Time frame: 24 months

Secondary outcomes

  1. Assessment of the reproducibility (precision under different measurement conditions: same participants scanned on separate MRI scanners at both 1.5T and 3T) of multiparametric MRI for the assessment of body composition and multiple organ metrics.

    To determine the reproducibility of multiparametric MRI in the assessment of body composition and multiple organ structures (liver, pancreas, aorta, heart, kidney, lungs and spleen) obtained within separate MR scanning sessions.

    Time frame: 24 months

Other outcomes

  1. Assessment of the mean differences in body composition and multiple organ metrics between healthy participants and those with type 2 diabetes acquired with multiparametric MRI.

    To determine the range of body composition and multi-organ metrics (liver, pancreas, aorta, heart, kidney, lungs and spleen) in healthy participants and in those with type 2 diabetes assessed using multiparametric MRI.

    Time frame: 24 months

07

Study locations

3 sites
  • Beaver House
    Oxford, OX1 2EH, United Kingdom
  • Oxford Centre for Magnetic Resonance
    Oxford, OX3 9DU, United Kingdom
  • Gemini One
    Oxford, OX4 2LL, United Kingdom
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 1, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04137705
Lead sponsor
Perspectum
Responsible party
Sponsor
First posted
Oct 24, 2019
Start date
Nov 4, 2019
Primary completion
Nov 25, 2023
Completion
Nov 25, 2023
Last update
Dec 1, 2025

Study contacts

Rajarshi Banerjee
study chair · Perspectum

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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