An observational study in Multiple, sponsored by Perspectum. Recruiting at 1 site in United Kingdom. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-20.
Sponsored by Perspectum · Observational
Cross-sectional observational study to improve MRI data acquisition techniques by optimising MRI sequences for multiple organs and assessing the repeatability and reproducibility of multiparametric MRI, in healthy volunteers.
This will be a cross-sectional, observational study recruiting up to 600 participants designed at improving MRI data acquisition techniques by optimising MRI sequences and assessing different aspects of the repeatability and reproducibility of multiparametric MRI. Participants will be recruited from Perspectum's own volunteer database, PIC Sites, as well as through advertisements on social media platforms (e.g. Facebook, Instagram), Perspectum's website, as well as through charities.
Suitable participants will be invited to attend a screening visit, normally over the telephone, which will involve eConsent process, collection of participant's self-reported medical evaluation to assess eligibility according to the inclusion and exclusion criteria, and demographics. Visit 1 will consist of the collection of basic anthropometric measurements (e.g. height, weight, waist circumference), a medical history, a MRI scan and optional standard clinical reference assessments. Visit 2- 9 will be a repeat of visit 1 tests and an update on the medical history .
Study participants will be adult volunteers aged 18 and over, without a contraindication to magnetic resonance imaging.
Exclusion Criteria:
Development of MRI sequences
Development of sequences which will be used to collect good quality data on multiple organs across different MRI scanners and to ensure that desirable images are obtained within reasonable amount of time.
Time frame: 7 years from study start
Sequence and parameter validation
Validation of a list of sequences and parameter details
Time frame: 7 years from study start
Assessment of MRI metric repeatability
Assessment of repeatability of the MRI metrics across 2 separate MRI acquisitions on the same scanner using statistical methods
Time frame: 7 years from study start
Assessment of MRI metric reproducibility
Assessment of reproducibility of the MRI metrics in the same participants scanned on separate MRI scanners
Time frame: 7 years from study start
Assessment of participant comfort during scan
Assessment of participant comfort during different MRI protocols with participant questionnaires.
Time frame: 7 years from study start
Assessment of Standard clinical reference assessment vs MRI
Assessment of agreement between MRI derived measures and standard clinical reference assessments (ultrasound, echocardiography), in the same participants, including repeatability for both methods where applicable.
Time frame: 7 years from study start
Plan to share: No
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