ClinicalTrials.gg
SuspendedNCT04135911PROMISEUpdated Jan 9, 2025

A Prospective Study on The"Management of Hypertension in Young and Middle-aged Subjects in Enterprises Setting"

An observational study in Hypertension and Blood Pressure, sponsored by Yan Li. Suspended at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-01-09.

Sponsored by Yan Li · Observational

Why this study was suspended
The study was suspended due to limited funding and the COVID-19 pandemic.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
2,000
Ages
18 Years to 65 Years
Sex
All
01

Study summary

In recent years, with the investment from government in the health management of the elderly, community management of hypertension in the elderly has made great progress in management rate and standardized management, but the management of young and middle-aged patients with hypertension is still blank.

Workplace pressure measurement may be more suitable for most of the young and middle-aged patients to find high blood pressure and monitor blood pressure changes in time.

However, there is not much research on workplace pressure measurement. Whether blood pressure measurement in the workplace can reduce the white coat effect, and how it relates to home blood pressure and ambulatory blood pressure is still unclear.

02

Conditions studied

  • Hypertension
  • Blood Pressure

Browse trials for

03

In context

Hypertension

6,114 studies on the registry are indexed under Hypertension; 912 are open to participants now.

This study's planned enrollment of 2,000 is above the median of 350 across 1,163 observational studies indexed under Hypertension.

Browse Hypertension studies →

Lead sponsor

Yan Li is the lead sponsor of 7 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients measuring blood pressure at the workplace with normal high blood pressure or hypertensive patients.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Male and female sex, aged 18-65 years
  2. Three different daytime workplace blood pressure measurements meet the limits: systolic blood pressure ≥ 120 mmHg, or diastolic blood pressure ≥80 mmHg
  3. Hypertensive patients who are taking antihypertensive drugs
  4. Willing to provide information about disease history and lifestyle
  5. Willing to receive follow-up for up to 2-3 years
  6. Sign the

Exclusion criteria

Exclusion Criteria:

  1. Having the onset of cardiovascular and cerebrovascular diseases such as stroke, myocardial infarction or heart failure within 6 months
  2. Having a history of atrial fibrillation or frequent arrhythmia
  3. Complicating other diseases that are not suitable for the trial, such as thyroid disease with active medication, acute infectious diseases, chronic mental illness, and tumors
  4. The subject is participating in other clinical studies.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
2,000 participants (estimated)
Target follow-up
2 Years
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. Diagnostic classification in hypertension

    Differences in diagnostic classification between workplace blood pressure and daytime ambulatory blood pressure in the classification of hypertension (masked hypertension or white coat hypertension)

    Time frame: 2 years

Secondary outcomes

  1. Change in different blood pressure measurement

    Differences in workplace blood pressure, daytime ambulatory blood pressure, home blood pressure and 24-hour ambulatory blood pressure

    Time frame: 2 years

  2. The distribution of heart rate in young and middle-aged subjects

    The distribution of heart rate in young and middle-aged subjects who were diagnosed with hypertension

    Time frame: 2 years

  3. Progression of target organ damage

    Differences in the progression of target organ damage between controlled or uncontrolled subjects or between subjects with fast and slow heart rate

    Time frame: 2 years

  4. The development of with-coat hypertension

    The development of white-coat hypertension as persistent hypertension and other types of hypertension or normal blood pressure and changes in target organ damage

    Time frame: 2 years

  5. The proportion of masked hypertension in patients with normal high blood pressure

    The proportion of masked hypertension in patients with normal high blood pressure and the change in outcome after treatment intervention and changes in target organ damage

    Time frame: 2 years

07

Study locations

1 site
  • Ruijin Hospital
    Shanghai, Shanghai 200025, China
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Dec 2019 (actual). Primary completion is estimated for Mar 2026, 75 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 21, 2019
First posted
Oct 23, 2019
StartActual
Dec 30, 2019
Primary completionEst.
Mar 31, 2026
CompletionEst.
Mar 31, 2026
Last update
Jan 9, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jan 9, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT04135911
Lead sponsor
Yan Li
Responsible party
Yan Li (Professor of Cardiovascular Medicine, Shanghai Institute of Hypertension) — Sponsor-investigator
First posted
Oct 23, 2019
Start date
Dec 30, 2019
Primary completion
Mar 31, 2026 (estimated)
Completion
Mar 31, 2026 (estimated)
Last update
Jan 9, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is suspended, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion