ClinicalTrials.gg
Status unknownNCT04107883Updated Nov 24, 2023

Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

An interventional study of fresh frozen plasma and blood sample in End Stage Liver DIsease and Liver Transplantation, sponsored by Beijing Chao Yang Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-11-24.

Sponsored by Beijing Chao Yang Hospital · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Nov 2023), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.

02

Conditions studied

  • End Stage Liver DIsease
  • Liver Transplantation

Keywords

  • endothelial
  • plasma
03

In context

End Stage Liver Disease

266 studies on the registry are indexed under End Stage Liver Disease; 61 are open to participants now.

This study's planned enrollment of 30 is below the median of 70 across 152 interventional studies indexed under End Stage Liver Disease.

Browse End Stage Liver Disease studies →

Lead sponsor

Beijing Chao Yang Hospital is the lead sponsor of 139 studies on the registry; 50 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Child A/B cirrhosis
  • patients who undergo the first OLT
  • Informed and consented
  • complete follow-up
  • cooperate with treatment

Exclusion criteria

Exclusion Criteria:

  • re-transplant
  • combined liver and other organ transplantation
  • BMI≥30Kg/m2
  • patients with hypertension, diabetes, coronary heart disease, chronic renal insufficiency, preoperative pulmonary infection, pleural effusion
  • acute liver failure
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    control group

    perform artificial colloidal solution transfusion during anhapetic phase.

    Diagnostic Test: blood sample

  • Experimental
    anhapetic group

    Perform plasma transfusion during anhapetic phase.

    Biological: fresh frozen plasma · Diagnostic Test: blood sample

Interventions

  • perform plasma transfusion in different phases during perioperation

  • Diagnostic testblood sample

    get blood samples at several specific points in time during perioperation

06

What researchers measure

Primary outcomes

  1. endothelial glycocalyx layer shedding markers

    plasma concentration of endothelial glycocalyx layer shedding markers

    Time frame: 24 hours

Secondary outcomes

  1. inflammatory cytokines

    levels of inflammatory cytokines

    Time frame: 24 hours

07

Study locations

1 of 1 sites recruiting
  • Capital Medical University Affiliated Beijing Chaoyang Hospital
    Beijing, Beijing Municipality 100020, China
    Recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 24, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04107883
Responsible party
Xun Liu (Principal Investigator, Beijing Chao Yang Hospital) — Principal investigator
First posted
Sep 27, 2019
Start date
Oct 1, 2023
Primary completion
Dec 31, 2024 (estimated)
Completion
Dec 31, 2024 (estimated)
Last update
Nov 24, 2023

Study contacts

Xun Liu
Contact
13466505725@163.com
+86 13466505725
Anshi Wu
Contact
wuanshi@hotmail.com
+86 010 85231330
Anshi Wu
study chair · Capital Medical University Affiliated Beijing Chaoyang Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Nov 2023. You cannot join it, but the record below documents what was studied.

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Studies of the drug tested here: Human plasma

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