An interventional study of Intrathecal morphine and Ultrasound guided supra-inguinal fascia iliaca block in Total Hip Replacement, Ultrasound Guided Supra-inguinal Fascia Iliaca Block and Intrathecal Morphine, sponsored by Mahidol University. Status unknown at 1 site in Thailand. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-02-27.
Sponsored by Mahidol University · Not applicable, Interventional, and Prevention
Total hip replacement is one of major orthopedic surgery which result in severe postoperative pain especially at first 24 hours. Ultrasound guided regional anesthesia has become a part of multimodal analgesia.Ultrasound guided supra-inguinal fascia iliaca block is a new technique which can consistently cover femoral and lateral femoral cutaneous nerve. And with large volume (40ml), it may cover obturator nerve. This technique already proved to be useful for acute pain control in hip fracture or postoperative control in dynamic hip screw or nail insertion operation. However, it has not been compared with intrathecal morphine for total hip replacement yet.
By using combine ultrasound guided supra-inguinal fascia iliaca block with periarticular infiltration with mutimodal analgesic drugs will have longer duration time to first rescue analgesic drug compared with combine intrathecal morphine with periarticular infiltration with multimodal analgesic drugs.
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This study's planned enrollment of 98 is above the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
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Exclusion Criteria:
Intrathecal morphine 0.1 mg, A sham subcutaneous injection of 0.5 ml normal saline at inguinal area
Drug: Intrathecal morphine
0.25% bupivacaine 40 ml
Drug: Ultrasound guided supra-inguinal fascia iliaca block
0.5% Iso/Hyperbaric bupivacaine 2-3 ml add morphine 0.1 mg for spinal anesthesia
Ultrasound guided supra-inguinal fascia iliaca block with 0.25% bupivacaine 40 ml and 0.5% Iso/Hyperbaric bupivacaine 2-3 ml without spinal morphine for spinal anesthesia
Time to first analgesic request (PCA fentanyl)
Whether ultrasound guided supra-inguinal fascia iliaca block can increase pain free period of patients undergo total hip replacement under spinal block compare with intrathecal morphine or not
Time frame: 48 hours
Pain score
Pain score at rest and on movement rating by numerical rating scale in 48-hr postoperative
Time frame: 48 hours
Amount of rescue analgesic drugs
Amount of PCA fentanyl
Time frame: 48 hours
Plan to share: No
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Mahidol University