An interventional study of 10% lidocaine sprayed and 2% lidocaine intravenous in Reducing Cough During Extubation, sponsored by Khon Kaen University. Completed at 1 site in Thailand. Open to participants aged 19 Years to 60 Years. Per ClinicalTrials.gov, last updated 2019-09-16.
Sponsored by Khon Kaen University · Not applicable, Interventional, and Treatment
Coughing during extubation of endotracheal tube (ETT) is a common problem that leads to poor surgical results including hemodynamic change, rebleeding at the surgical wound and wound dehiscence. Recently, lidocaine has been introduced for reducing coughing during extubation. However, data comparing routes of lidocaine application are lacking, thus, this study compared the combination of lidocaine sprayed on laryngeal inlet and cuff of ETT versus intravenous lidocaine injection for efficacy in reducing coughing
A prospective randomized control trial was conduct with 164 patients. They were randomly allocated into Gr. A and B. Group A received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet whereas Gr. B received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation. The same general anesthesia protocol was applied in all of the patients. Incidence and severity of cough during extubation was evaluated. Furthermore, incidence of 24-hour postoperative adverse events (including sore throat, dysphagia, and hoarseness) and hemodynamic response after extubation were analyzed.
346 studies on the registry are indexed under Cough; 71 are open to participants now.
This study's enrollment of 164 is above the median of 70 across 263 interventional studies indexed under Cough.
Browse Cough studies →Khon Kaen University is the lead sponsor of 160 studies on the registry; 24 are open to participants now.
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Exclusion Criteria:
Patients received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet
Drug: 10% lidocaine sprayed
Patients received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation
Drug: 2% lidocaine intravenous
four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet
Also known as: 10% Xylociane
15 mg/kg of 2% lidocaine intravenous injection prior to extubation
Also known as: 2% Xylocaine
Change in incidence of coughing
Coughing event was recorded by blinded anesthesiologist
Time frame: the incidence was recorded during extubation and immediatly extubation
Severity of coughing
the severity of cough was recorded by blinded anesthesiologist. Coughing level severity (16) was evaluated as 0 = no cough; 1 = slight cough, cough without obvious contraction of abdomen; 2 = moderate cough, strong and sudden contraction of the abdomen lasting less than 5 seconds; 3 = severe cough, strong and sudden contraction of the abdomen sustained more than 5 seconds
Time frame: the severity was recorded during extubation and immediatly extubation
Incidence of postoperative sore throat
Incidence of postoperative sore throat was recorded by two blinded anesthetist nurses . The numeric rating scale (0 = no, 10 = extreme) was used for evaluation of sore throat. If the numeric rating scale was more than 3, it was considered as a significant adverse event.
Time frame: the incidence was recorded within 24 hr after extubation
Incidence of dysphonia
Incidence of dysphonia was recorded by two blinded anesthetist nurses .
Time frame: the incidence was recorded within 24 hr after extubation
Incidence of dysphagia
Incidence of dysphagia was recorded by two blinded anesthetist nurses .
Time frame: the incidence was recorded within 24 hr after extubation
This study is completed, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.
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Khon Kaen University